INCRELEX (mecasermin)
PRIMARY INSULIN-LIKE GROWTH FACTOR-1 DEFICIENCY
TERCICA INC
Indication
Primary insulin-like growth factor-1 deficiency
Primary insulin-like growth factor-1 deficiency is a rare endocrine disorder primarily affecting pediatric populations, marked by marked failure of linear growth and skeletal development. Read more about Primary insulin-like growth factor-1 deficiency
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INCRELEX (mecasermin)
INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) AGENTS·PRIMARY INSULIN-LIKE GROWTH FACTOR-1 DEFICIENCY
IPSEN BIOPHARMA
INCRELEX (mecasermin)
INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) AGENTS·PRIMARY INSULIN-LIKE GROWTH FACTOR-1 DEFICIENCY
ETON PHARMACEUT
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Coming soonPrimary insulin-like growth factor-1 deficiency is a rare endocrine disorder primarily affecting pediatric populations, marked by marked failure of linear growth and skeletal development.
It arises from disruptions along the growth hormone–insulin-like growth factor axis, caused by genetic mutations affecting the growth hormone receptor, post-receptor intracellular signaling cascades, or the insulin-like growth factor-1 gene itself.
Pathophysiologically, it is defined by abnormally low circulating levels of insulin-like growth factor-1 in the presence of normal or elevated growth hormone secretion, distinguishing it from hypopituitary growth hormone deficiency and secondary causes of growth attenuation.
Clinically, affected individuals present with pronounced short stature, delayed bone age, and variable dysmorphic or metabolic features, such as frontotemporal prominentia and episodic hypoglycemia.
- nih.gov
Primary insulin-like growth factor-1 deficiency is a rare endocrine disorder primarily affecting pediatric populations, marked by marked failure of linear growth and skeletal development It arises from disruptions along the growth hormone–insulin-like growth factor axis, caused by genetic mutations affecting the growth hormone receptor, post-receptor intracellular signaling cascades, or the insulin-like growth factor-1 gene itself Clinically, affected individuals present with pronounced short st...
- nih.gov
Primary insulin-like growth factor-1 deficiency is a rare endocrine disorder primarily affecting pediatric populations, marked by marked failure of linear growth and skeletal development Pathophysiologically, it is defined by abnormally low circulating levels of insulin-like growth factor-1 in the presence of normal or elevated growth hormone secretion, distinguishing it from hypopituitary growth hormone deficiency and secondary causes of growth attenuation
- magicfoundation.org
Primary insulin-like growth factor-1 deficiency is a rare endocrine disorder primarily affecting pediatric populations, marked by marked failure of linear growth and skeletal development Pathophysiologically, it is defined by abnormally low circulating levels of insulin-like growth factor-1 in the presence of normal or elevated growth hormone secretion, distinguishing it from hypopituitary growth hormone deficiency and secondary causes of growth attenuation
- genome.jp
It arises from disruptions along the growth hormone–insulin-like growth factor axis, caused by genetic mutations affecting the growth hormone receptor, post-receptor intracellular signaling cascades, or the insulin-like growth factor-1 gene itself
- nih.gov
Pathophysiologically, it is defined by abnormally low circulating levels of insulin-like growth factor-1 in the presence of normal or elevated growth hormone secretion, distinguishing it from hypopituitary growth hormone deficiency and secondary causes of growth attenuation
- checkrare.com
Clinically, affected individuals present with pronounced short stature, delayed bone age, and variable dysmorphic or metabolic features, such as frontotemporal prominentia and episodic hypoglycemia
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