Prostatic carcinoma

Prostatic carcinoma is a malignant epithelial neoplasm arising from the glandular tissue of the prostate, primarily affecting older men

Prostatic carcinoma is a malignant epithelial neoplasm arising from the glandular tissue of the prostate, primarily affecting older men The vast majority of cases are adenocarcinomas that originate in the peripheral zone of the prostate gland and are typically driven by androgen receptor signaling Pathophysiologically, it is characterized by glandular atypia, loss of basal epithelial cells, and variable histologic differentiation, which is clinically graded using the Gleason scoring system and m...

The vast majority of cases are adenocarcinomas that originate in the peripheral zone of the prostate gland and are typically driven by androgen receptor signaling While early-stage disease is frequently indolent and asymptomatic, progression can lead to lower urinary tract obstruction, hematuria, or metastatic dissemination predominantly to regional lymph nodes and the axial skeleton

While early-stage disease is frequently indolent and asymptomatic, progression can lead to lower urinary tract obstruction, hematuria, or metastatic dissemination predominantly to regional lymph nodes and the axial skeleton

Pathophysiologically, it is characterized by glandular atypia, loss of basal epithelial cells, and variable histologic differentiation, which is clinically graded using the Gleason scoring system and monitored via serum prostate-specific antigen levels