Prosthetic arthroplasty infection prevention

Prosthetic arthroplasty infection prevention refers to the prophylactic clinical strategies, primarily perioperative antimicrobial administration, intended to reduce the incidence of periprosthetic joint infection in musculoskeletal surgical patients undergoing total or partial joint replacement Periprosthetic joint infection is a severe surgical site complication characterized by microbial contamination—most frequently by *Staphylococcus aureus* or coagulase-negative staphylococci—and subsequen...

Prosthetic arthroplasty infection prevention refers to the prophylactic clinical strategies, primarily perioperative antimicrobial administration, intended to reduce the incidence of periprosthetic joint infection in musculoskeletal surgical patients undergoing total or partial joint replacement

Periprosthetic joint infection is a severe surgical site complication characterized by microbial contamination—most frequently by *Staphylococcus aureus* or coagulase-negative staphylococci—and subsequent biofilm formation on the foreign implant surfaces and adjacent bone or soft tissue

Preventing this condition is critical, as established biofilm-associated infections can lead to severe joint pain, local tissue destruction, osteolysis, mechanical implant loosening, systemic sepsis, and the requirement for complex revision surgeries