Prurigo nodularis

Prurigo nodularis is a chronic, inflammatory neuroimmune dermatologic disorder that most commonly affects middle-aged to older adults and individuals with atopic diathesis or chronic pruritic systemic conditions It is clinically characterized by the development of multiple, firm, intensely pruritic, hyperkeratotic papules and nodules that typically exhibit a symmetric distribution over the extensor surfaces of the limbs and the trunk Pathophysiologically, the disease is sustained by a dysregulat...

Prurigo nodularis is a chronic, inflammatory neuroimmune dermatologic disorder that most commonly affects middle-aged to older adults and individuals with atopic diathesis or chronic pruritic systemic conditions

Prurigo nodularis is a chronic, inflammatory neuroimmune dermatologic disorder that most commonly affects middle-aged to older adults and individuals with atopic diathesis or chronic pruritic systemic conditions Pathophysiologically, the disease is sustained by a dysregulated itch-scratch cycle involving complex neuroimmune crosstalk, characterized by cutaneous neural hyperplasia, local release of neuropeptides, and type 2 helper T-cell-mediated cytokine signaling that drives recalcitrant neurog...

It is clinically characterized by the development of multiple, firm, intensely pruritic, hyperkeratotic papules and nodules that typically exhibit a symmetric distribution over the extensor surfaces of the limbs and the trunk

Pathophysiologically, the disease is sustained by a dysregulated itch-scratch cycle involving complex neuroimmune crosstalk, characterized by cutaneous neural hyperplasia, local release of neuropeptides, and type 2 helper T-cell-mediated cytokine signaling that drives recalcitrant neurogenic inflammation and epidermal thickening