Pruritus in hemodialysis-dependent chronic kidney disease

Pruritus in hemodialysis-dependent chronic kidney disease, historically termed uremic pruritus or chronic kidney disease-associated pruritus, is a debilitating systemic symptom characterized by persistent or recurrent itching without an underlying primary dermatologic cause It specifically affects patients with end-stage renal disease who require maintenance hemodialysis, presenting as localized or generalized, often bilaterally symmetrical discomfort that commonly disrupts sleep and reduces qua...

It specifically affects patients with end-stage renal disease who require maintenance hemodialysis, presenting as localized or generalized, often bilaterally symmetrical discomfort that commonly disrupts sleep and reduces quality of life

It specifically affects patients with end-stage renal disease who require maintenance hemodialysis, presenting as localized or generalized, often bilaterally symmetrical discomfort that commonly disrupts sleep and reduces quality of life

The underlying pathophysiology is multifactorial and involves uremic toxin retention, systemic microinflammation with pro-inflammatory cytokine signaling, cutaneous xerosis, peripheral neuropathy, and central nervous system dysregulation marked by an imbalance between mu- and kappa-opioid receptor pathways

The underlying pathophysiology is multifactorial and involves uremic toxin retention, systemic microinflammation with pro-inflammatory cytokine signaling, cutaneous xerosis, peripheral neuropathy, and central nervous system dysregulation marked by an imbalance between mu- and kappa-opioid receptor pathways