Indication

Pustular psoriasis

Pustular psoriasis is a rare, severe variant of psoriasis characterized by the eruption of sterile, macroscopic pustules on an erythematous, inflamed base. Read more about Pustular psoriasis

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About Pustular psoriasis.

Pustular psoriasis is a rare, severe variant of psoriasis characterized by the eruption of sterile, macroscopic pustules on an erythematous, inflamed base.

Primarily affecting the integumentary system, it can present in localized patterns, such as on the palms and soles, or as a generalized eruption that can cause life-threatening systemic inflammation, fever, and metabolic disturbances.

Pathophysiologically, the condition is driven by intense neutrophilic infiltration into the epidermis, predominantly mediated by innate immune dysregulation along the interleukin-36 signaling pathway.

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