Radiation-induced mucositis

Radiation-induced mucositis is an acute, debilitating inflammatory condition of the mucosal lining that occurs as a normal-tissue complication of ionizing radiation exposure, most frequently observed in patients receiving radiotherapy for head and neck cancers It is pathophysiologically driven by radiation-triggered DNA damage, reactive oxygen species generation, and pro-inflammatory cytokine signaling, which impair basal epithelial renewal and cause progressive mucosal atrophy Clinically, the c...

Radiation-induced mucositis is an acute, debilitating inflammatory condition of the mucosal lining that occurs as a normal-tissue complication of ionizing radiation exposure, most frequently observed in patients receiving radiotherapy for head and neck cancers

It is pathophysiologically driven by radiation-triggered DNA damage, reactive oxygen species generation, and pro-inflammatory cytokine signaling, which impair basal epithelial renewal and cause progressive mucosal atrophy

Clinically, the condition manifests as intense erythema, edema, and mucosal ulcerations, typically leading to severe pain, dysphagia, malnutrition, and an increased vulnerability to secondary local or systemic infections

Clinically, the condition manifests as intense erythema, edema, and mucosal ulcerations, typically leading to severe pain, dysphagia, malnutrition, and an increased vulnerability to secondary local or systemic infections