Indication

Relapsed follicular B-cell non-Hodgkin lymphoma

Relapsed follicular B-cell non-Hodgkin lymphoma describes a recurrent malignancy of the lymphatic system originating from germinal center B cells that reappears following a prior period of treatment-induced complete or partial remission. Read more about Relapsed follicular B-cell non-Hodgkin lymphoma

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About Relapsed follicular B-cell non-Hodgkin lymphoma.

Relapsed follicular B-cell non-Hodgkin lymphoma describes a recurrent malignancy of the lymphatic system originating from germinal center B cells that reappears following a prior period of treatment-induced complete or partial remission.

Predominantly affecting older adults, this indolent lymphoproliferative disorder characteristically involves the lymph nodes, spleen, and bone marrow.

It is pathophysiologically defined by abnormal follicular architecture and sustained cell survival, most often driven by the t(14;18) chromosomal translocation that causes BCL2 overexpression.

Clinically, recurrence presents as newly enlarged or progressive painless lymphadenopathy, organomegaly, cytopenias, or constitutional B symptoms after prior therapy.

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