Indication

Scleroderma

Scleroderma is a rare, chronic autoimmune connective tissue disorder characterized by microvascular dysfunction, immune dysregulation, and excessive extracellular matrix deposition leading to progressive fibrosis. Read more about Scleroderma

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About Scleroderma.

Scleroderma is a rare, chronic autoimmune connective tissue disorder characterized by microvascular dysfunction, immune dysregulation, and excessive extracellular matrix deposition leading to progressive fibrosis.

It encompasses localized scleroderma, which primarily affects the skin and subcutaneous tissues, and systemic sclerosis, which involves extensive cutaneous thickening alongside internal organ complications affecting the lungs, heart, kidneys, and gastrointestinal tract.

Most commonly diagnosed in adults between 30 and 50 years of age with a marked female predominance, hallmark clinical features include Raynaud phenomenon, cutaneous sclerosis, telangiectasias, digital ulcers, and organ-specific fibrotic or vascular pathology.

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