Indication

SIADH syndrome

SIADH syndrome (syndrome of inappropriate antidiuretic hormone secretion) is an endocrine and fluid-electrolyte disorder characterized by the unsuppressed, non-physiologic release of antidiuretic hormone or enhanced sensitivity of renal vasopressin receptors. Read more about SIADH syndrome

8 drugs 7 manufacturers

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Drugs that treat it

Common SIADH syndrome therapies.

Showing 1–8 of 8 drugs

SAMSCA (tolvaptan)

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
Otsuka Pharmaceutical Co., Ltd.

JYNARQUE (tolvaptan)

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
Otsuka Pharmaceutical Co., Ltd.

TOLVAPTAN

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
CAMBER PHARMACE

TOLVAPTAN

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
PAR HEALTH USA,

TOLVAPTAN

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
APOTEX CORP

TOLVAPTAN

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
ASCEND LABORATO

TOLVAPTAN

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
NOVADOZ PHARMAC

TOLVAPTAN

ANTIDIURETIC HORMONE ANTAGONISTS·SIADH SYNDROME·+1
NORTHSTAR RX LL
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About SIADH syndrome.

SIADH syndrome (syndrome of inappropriate antidiuretic hormone secretion) is an endocrine and fluid-electrolyte disorder characterized by the unsuppressed, non-physiologic release of antidiuretic hormone or enhanced sensitivity of renal vasopressin receptors.

It predominantly impacts the renal and central nervous systems, frequently arising secondary to malignancies, pulmonary infections, intracranial pathologies, or various pharmacologic agents.

Pathophysiologically, excessive hormone activity promotes persistent water reabsorption in the renal collecting ducts, leading to impaired free water excretion, hyperconcentrated urine, and dilutional, euvolemic hypotonic hyponatremia.

Clinically, affected individuals are classically euvolemic without edema, but secondary cellular swelling and cerebral edema can cause symptoms ranging from headache, nausea, and lethargy to severe neurocognitive impairment, seizures, and coma.

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