Indication
SIADH syndrome
SIADH syndrome (syndrome of inappropriate antidiuretic hormone secretion) is an endocrine and fluid-electrolyte disorder characterized by the unsuppressed, non-physiologic release of antidiuretic hormone or enhanced sensitivity of renal vasopressin receptors. Read more about SIADH syndrome
8 drugs 7 manufacturers
Drugs that treat it
Common SIADH syndrome therapies.
JYNARQUE (tolvaptan)
TOLVAPTAN
TOLVAPTAN
TOLVAPTAN
TOLVAPTAN
TOLVAPTAN
TOLVAPTAN
News & literature
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Coming soonSIADH syndrome (syndrome of inappropriate antidiuretic hormone secretion) is an endocrine and fluid-electrolyte disorder characterized by the unsuppressed, non-physiologic release of antidiuretic hormone or enhanced sensitivity of renal vasopressin receptors.
It predominantly impacts the renal and central nervous systems, frequently arising secondary to malignancies, pulmonary infections, intracranial pathologies, or various pharmacologic agents.
Pathophysiologically, excessive hormone activity promotes persistent water reabsorption in the renal collecting ducts, leading to impaired free water excretion, hyperconcentrated urine, and dilutional, euvolemic hypotonic hyponatremia.
Clinically, affected individuals are classically euvolemic without edema, but secondary cellular swelling and cerebral edema can cause symptoms ranging from headache, nausea, and lethargy to severe neurocognitive impairment, seizures, and coma.
- nih.gov
SIADH syndrome (syndrome of inappropriate antidiuretic hormone secretion) is an endocrine and fluid-electrolyte disorder characterized by the unsuppressed, non-physiologic release of antidiuretic hormone or enhanced sensitivity of renal vasopressin receptors
- nih.gov
SIADH syndrome (syndrome of inappropriate antidiuretic hormone secretion) is an endocrine and fluid-electrolyte disorder characterized by the unsuppressed, non-physiologic release of antidiuretic hormone or enhanced sensitivity of renal vasopressin receptors It predominantly impacts the renal and central nervous systems, frequently arising secondary to malignancies, pulmonary infections, intracranial pathologies, or various pharmacologic agents
- nih.gov
It predominantly impacts the renal and central nervous systems, frequently arising secondary to malignancies, pulmonary infections, intracranial pathologies, or various pharmacologic agents
- medlineplus.gov
Pathophysiologically, excessive hormone activity promotes persistent water reabsorption in the renal collecting ducts, leading to impaired free water excretion, hyperconcentrated urine, and dilutional, euvolemic hypotonic hyponatremia Clinically, affected individuals are classically euvolemic without edema, but secondary cellular swelling and cerebral edema can cause symptoms ranging from headache, nausea, and lethargy to severe neurocognitive impairment, seizures, and coma
- nih.gov
Pathophysiologically, excessive hormone activity promotes persistent water reabsorption in the renal collecting ducts, leading to impaired free water excretion, hyperconcentrated urine, and dilutional, euvolemic hypotonic hyponatremia
- nih.gov
Clinically, affected individuals are classically euvolemic without edema, but secondary cellular swelling and cerebral edema can cause symptoms ranging from headache, nausea, and lethargy to severe neurocognitive impairment, seizures, and coma
- nih.gov
Clinically, affected individuals are classically euvolemic without edema, but secondary cellular swelling and cerebral edema can cause symptoms ranging from headache, nausea, and lethargy to severe neurocognitive impairment, seizures, and coma
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