Indication

Smallpox vaccination

Smallpox vaccination is a preventive medical intervention indicated for active immunization against smallpox, a severe and potentially fatal systemic infection caused by the variola virus, an orthopoxvirus. Read more about Smallpox vaccination

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About Smallpox vaccination.

Smallpox vaccination is a preventive medical intervention indicated for active immunization against smallpox, a severe and potentially fatal systemic infection caused by the variola virus, an orthopoxvirus.

Although eradicated naturally from the global population, the threat of accidental release or bioterrorism necessitates targeted prophylaxis, primarily indicated for individuals at high risk of exposure, such as designated military personnel, public health responders, and laboratory workers handling related orthopoxviruses.

Pathophysiologically, the vaccine utilizes related vaccinia virus formulations to elicit neutralizing antibodies and cell-mediated immunity, thereby preventing variola virus entry, systemic viremia, and the characteristic febrile prodrome and centrifugal vesiculopustular rash.

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