Smallpox

Smallpox is a severe, highly contagious, and potentially fatal systemic infection caused by the variola virus, an orthopoxvirus that exclusively infects humans

Smallpox is a severe, highly contagious, and potentially fatal systemic infection caused by the variola virus, an orthopoxvirus that exclusively infects humans The disease begins with a febrile prodrome characterized by high fever, severe headache, backache, and prostration Severe presentations can involve widespread multiorgan involvement, hemorrhagic manifestations, or secondary bacterial complications, carrying significant historic morbidity and mortality

The disease begins with a febrile prodrome characterized by high fever, severe headache, backache, and prostration This is followed by mucosal enanthema and an acute, centrifugally distributed exanthem that progresses synchronously across the face and extremities from macules and papules to firm, deep-seated, umbilicated vesicles and pustules that eventually crust and desquamate Severe presentations can involve widespread multiorgan involvement, hemorrhagic manifestations, or secondary bacterial...

This is followed by mucosal enanthema and an acute, centrifugally distributed exanthem that progresses synchronously across the face and extremities from macules and papules to firm, deep-seated, umbilicated vesicles and pustules that eventually crust and desquamate