Smoldering myeloma

Smoldering myeloma (also termed smoldering multiple myeloma) is an asymptomatic, premalignant clonal plasma cell proliferative disorder affecting the hematologic system and bone marrow It represents an intermediate clinical stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic multiple myeloma, carrying a significantly higher risk of malignant progression

Smoldering myeloma (also termed smoldering multiple myeloma) is an asymptomatic, premalignant clonal plasma cell proliferative disorder affecting the hematologic system and bone marrow The condition is clinically defined by the presence of a serum monoclonal protein (M-protein) of at least 3.0 g/dL, urinary monoclonal protein of at least 500 mg per 24 hours, and/or 10% to 60% clonal bone marrow plasma cell infiltration Crucially, it occurs in the absence of myeloma-defining events, lacking end-o...

It represents an intermediate clinical stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic multiple myeloma, carrying a significantly higher risk of malignant progression

The condition is clinically defined by the presence of a serum monoclonal protein (M-protein) of at least 3.0 g/dL, urinary monoclonal protein of at least 500 mg per 24 hours, and/or 10% to 60% clonal bone marrow plasma cell infiltration

Crucially, it occurs in the absence of myeloma-defining events, lacking end-organ damage such as hypercalcemia, renal insufficiency, anemia, or lytic bone lesions (CRAB criteria), as well as specific high-risk SLiM biomarkers