Squamous cell carcinoma of skin

Squamous cell carcinoma of the skin is a malignant non-melanoma cutaneous neoplasm arising from epidermal keratinocytes

Squamous cell carcinoma of the skin is a malignant non-melanoma cutaneous neoplasm arising from epidermal keratinocytes

It primarily affects the integumentary system, most commonly emerging in older adults, fair-skinned individuals, and immunocompromised populations on chronically sun-exposed anatomical sites such as the head, neck, and extremities Clinically, it typically manifests as an indurated, hyperkeratotic papule, scaly plaque, or ulcerated nodule with potential for destructive local extension and regional lymph node metastasis

It primarily affects the integumentary system, most commonly emerging in older adults, fair-skinned individuals, and immunocompromised populations on chronically sun-exposed anatomical sites such as the head, neck, and extremities

It primarily affects the integumentary system, most commonly emerging in older adults, fair-skinned individuals, and immunocompromised populations on chronically sun-exposed anatomical sites such as the head, neck, and extremities Pathophysiologically driven by cumulative ultraviolet radiation that induces somatic mutations—notably within the *TP53* tumor suppressor gene—the malignancy is characterized by atypical keratinocyte proliferation with dermal invasion Clinically, it typically manifests...