Systemic anaplastic large cell lymphoma

Systemic anaplastic large cell lymphoma is an aggressive subtype of mature T-cell non-Hodgkin lymphoma that affects the lymphatic system and frequently disseminates to extranodal sites, including the bone, liver, lungs, soft tissue, and skin

Systemic anaplastic large cell lymphoma is an aggressive subtype of mature T-cell non-Hodgkin lymphoma that affects the lymphatic system and frequently disseminates to extranodal sites, including the bone, liver, lungs, soft tissue, and skin It is pathologically defined by widespread nodal effacement by large, pleomorphic lymphoid cells exhibiting universal, strong cell-surface expression of CD30 Clinically and molecularly, the disease is stratified into anaplastic lymphoma kinase (ALK)–positive...

Systemic anaplastic large cell lymphoma is an aggressive subtype of mature T-cell non-Hodgkin lymphoma that affects the lymphatic system and frequently disseminates to extranodal sites, including the bone, liver, lungs, soft tissue, and skin

It is pathologically defined by widespread nodal effacement by large, pleomorphic lymphoid cells exhibiting universal, strong cell-surface expression of CD30 Clinically and molecularly, the disease is stratified into anaplastic lymphoma kinase (ALK)–positive and ALK-negative forms; ALK-positive disease typically involves recurrent chromosomal translocations, occurs primarily in children and young adults, and carries a more favorable prognosis, whereas ALK-negative disease predominantly arises in...

Clinically and molecularly, the disease is stratified into anaplastic lymphoma kinase (ALK)–positive and ALK-negative forms; ALK-positive disease typically involves recurrent chromosomal translocations, occurs primarily in children and young adults, and carries a more favorable prognosis, whereas ALK-negative disease predominantly arises in older adults and follows a more refractory clinical course