Tertiary bejel

Tertiary bejel represents the late, destructive stage of endemic nonvenereal syphilis caused by the spirochete bacterium *Treponema pallidum* subspecies *endemicum*

Tertiary bejel represents the late, destructive stage of endemic nonvenereal syphilis caused by the spirochete bacterium *Treponema pallidum* subspecies *endemicum* Primarily affecting populations in arid, resource-limited regions—frequently arising years after initial childhood exposure—this phase predominantly impacts the skeletal system, mucocutaneous tissues, and upper respiratory tract Pathophysiologically, it is characterized by chronic granulomatous inflammation leading to destructive gum...

Primarily affecting populations in arid, resource-limited regions—frequently arising years after initial childhood exposure—this phase predominantly impacts the skeletal system, mucocutaneous tissues, and upper respiratory tract Pathophysiologically, it is characterized by chronic granulomatous inflammation leading to destructive gummatous lesions, chronic osteoperiostitis of long bones, and extensive ulceration with necrosis of the palate and nasal cartilage, causing profound facial disfigureme...

Pathophysiologically, it is characterized by chronic granulomatous inflammation leading to destructive gummatous lesions, chronic osteoperiostitis of long bones, and extensive ulceration with necrosis of the palate and nasal cartilage, causing profound facial disfigurement Unlike tertiary venereal syphilis, cardiovascular and central nervous system involvement is classically absent