Tertiary syphilis

Tertiary syphilis is a late, slowly progressive stage of systemic infection caused by the spirochete *Treponema pallidum*, developing years to decades after the initial untreated or inadequately treated infection

Tertiary syphilis is a late, slowly progressive stage of systemic infection caused by the spirochete *Treponema pallidum*, developing years to decades after the initial untreated or inadequately treated infection It predominantly affects adults and involves multiple organ systems, most notably the cardiovascular system, central nervous system, musculoskeletal structures, and skin Pathophysiologically driven by chronic endarteritis obliterans and delayed-type hypersensitivity granulomatous inflam...

It predominantly affects adults and involves multiple organ systems, most notably the cardiovascular system, central nervous system, musculoskeletal structures, and skin

Pathophysiologically driven by chronic endarteritis obliterans and delayed-type hypersensitivity granulomatous inflammation, it classically manifests as destructive gummatous lesions, cardiovascular syphilis such as ascending aortitis and aortic aneurysms, or late neurosyphilis presentations including general paresis and tabes dorsalis