ILARIS (canakinumab/PF)
ANTI-INFLAMMATORY - INTERLEUKIN 1 RECEPTOR ANTAGONIST·ACUTE GOUTY ARTHRITIS·+7
Novartis Pharmaceuticals
Indication
TNF receptor-associated periodic fever syndrome
TNF receptor-associated periodic fever syndrome (TRAPS) is a rare, autosomal dominant autoinflammatory disorder caused by pathogenic variants in the *TNFRSF1A* gene, which encodes the type 1 tumor necrosis factor receptor. Read more about TNF receptor-associated periodic fever syndrome
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Common TNF receptor-associated periodic fever syndrome therapies.
ILARIS (PF) (canakinumab/PF)
ANTI-INFLAMMATORY - INTERLEUKIN 1 RECEPTOR ANTAGONIST·ACUTE GOUTY ARTHRITIS·+7
Novartis Pharmaceuticals
ILARIS (canakinumab/PF)
ANTI-INFLAMMATORY - INTERLEUKIN 1 RECEPTOR ANTAGONIST·ACUTE GOUTY ARTHRITIS·+7
Novartis Pharmaceuticals
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Coming soonTNF receptor-associated periodic fever syndrome (TRAPS) is a rare, autosomal dominant autoinflammatory disorder caused by pathogenic variants in the *TNFRSF1A* gene, which encodes the type 1 tumor necrosis factor receptor.
This defect results in altered receptor trafficking, defective clearance, and excessive systemic inflammation driven primarily by interleukin-1 signaling.
The condition most commonly presents during childhood, although adult onset can occur, and it affects multiple organ systems.
Clinically, it is characterized by recurrent, prolonged inflammatory attacks typically lasting one to three weeks.
Hallmark manifestations include high spiking fevers, migratory myalgias with overlying tender erythema, severe abdominal pain, arthralgia, and periorbital edema, with systemic AA amyloidosis representing the most significant long-term complication.
- nih.gov
TNF receptor-associated periodic fever syndrome (TRAPS) is a rare, autosomal dominant autoinflammatory disorder caused by pathogenic variants in the *TNFRSF1A* gene, which encodes the type 1 tumor necrosis factor receptor This defect results in altered receptor trafficking, defective clearance, and excessive systemic inflammation driven primarily by interleukin-1 signaling The condition most commonly presents during childhood, although adult onset can occur, and it affects multiple organ systems...
- merckmanuals.com
TNF receptor-associated periodic fever syndrome (TRAPS) is a rare, autosomal dominant autoinflammatory disorder caused by pathogenic variants in the *TNFRSF1A* gene, which encodes the type 1 tumor necrosis factor receptor This defect results in altered receptor trafficking, defective clearance, and excessive systemic inflammation driven primarily by interleukin-1 signaling Clinically, it is characterized by recurrent, prolonged inflammatory attacks typically lasting one to three weeks Hallmark m...
- rarediseases.org
The condition most commonly presents during childhood, although adult onset can occur, and it affects multiple organ systems
- medlineplus.gov
Clinically, it is characterized by recurrent, prolonged inflammatory attacks typically lasting one to three weeks
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