Vaccination to prevent anal cancer due to human papillomavirus

Anal cancer due to human papillomavirus (HPV) is a malignancy arising from the mucosal or squamous epithelium of the anal canal and perianal region, predominantly manifesting as squamous cell carcinoma

Anal cancer due to human papillomavirus (HPV) is a malignancy arising from the mucosal or squamous epithelium of the anal canal and perianal region, predominantly manifesting as squamous cell carcinoma

Pathophysiologically, persistent infection with high-risk oncogenic HPV subtypes—most notably HPV-16 and HPV-18—drives cellular transformation through viral oncoproteins that disrupt host tumor suppressor pathways, progressing through precancerous anal intraepithelial neoplasia (dysplasia)

Pathophysiologically, persistent infection with high-risk oncogenic HPV subtypes—most notably HPV-16 and HPV-18—drives cellular transformation through viral oncoproteins that disrupt host tumor suppressor pathways, progressing through precancerous anal intraepithelial neoplasia (dysplasia)

Pathophysiologically, persistent infection with high-risk oncogenic HPV subtypes—most notably HPV-16 and HPV-18—drives cellular transformation through viral oncoproteins that disrupt host tumor suppressor pathways, progressing through precancerous anal intraepithelial neoplasia (dysplasia) While relatively rare in the general population, it disproportionately affects immunocompromised individuals, including people living with HIV, solid organ transplant recipients, and men who have sex with men ...

While relatively rare in the general population, it disproportionately affects immunocompromised individuals, including people living with HIV, solid organ transplant recipients, and men who have sex with men

While relatively rare in the general population, it disproportionately affects immunocompromised individuals, including people living with HIV, solid organ transplant recipients, and men who have sex with men

Clinically, affected patients may remain asymptomatic or develop local symptoms such as rectal bleeding, anal pain, pruritus, tenesmus, or a palpable anal mass