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The Funding statement for this article is incorrect. The correct Funding statement is as follows: This study was financially supported by MSD for Mothers in the form of a grant awarded to and administered to the authors by Jhpiego Corporation. No additional external funding was received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The Competing Interests statement for this article is incorrect. The...
Pregnancy
Okoli U, Obafemi S, Okpe C, Njoku K, Mobisson N, Uzoama C, Omoera V, Ugwa E, Hill K•
Background Lifestyle-related risk factors (LRRFs) are major contributors to adverse maternal and child outcomes. Despite clear international guidelines, counselling on these topics is inconsistently implemented in routine care. Structured tools may support comprehensive, consistent counselling, yet evidence for multi-domain approaches in maternal health is limited. Methods This exploratory longitudinal pilot feasibility study evaluated a structured counselling approach to support structured c...
Temporomandibular joint osteoarthritis (TMJOA) is a complex joint disorder characterized by progressive degradation of the cartilage matrix and apoptosis of chondrocytes; however, hypoxia-inducible factor 1α (HIF-1α) serves a positive role in maintaining the stability of the articular cartilage matrix. Therefore, the present study aimed to determine the expression levels of HIF-1α in the cartilage tissue of rats with TMJOA, and to explore its association with the proliferation of chondrocytes an...
Osteoarthritis
Liu L, Shi X, Li X, Lin Y, Yang H, Zhang J, Yang C•
Background Ankylosing spondylitis mainly affects people in early and middle adulthood. This period involves important transitions in education, career, relationships, and family. Illness perceptions play an important role in treatment adherence and disease management. Few qualitative studies have examined how Chinese adults perceive and cope with the disease using a clear theoretical framework. Objective This study aimed to explore illness perceptions among adults aged 18–44 years with ankylo...
Ankylosing Spondylitis
Zhu D, Wang B, Li Y, Nie X, Yin H, Huang S, Wang Q, Xu R•
Permafrost thaw has been identified as a cause of metal mobilization from acid rock drainage and transport to Arctic rivers. Elevated metal concentrations and precipitation of Fe(III) minerals (i.e., rusting) in surface waters deteriorates water quality and raises questions about ecosystem effects, especially to the health of fish species. Environmental DNA (eDNA) analyses could be used for assessing impacts of acid rock drainage to fish assemblages but may be prone to biases like polymerase cha...
Introduction Sexual and gender minority populations experience disproportionately high rates of mental disorders due, in large part, to their chronic exposure to stigma, discrimination, and minority stress. Cognitive behavioral therapy (CBT) is an established evidence-based psychotherapy; however, conventional CBT was primarily developed among predominantly cisgender, heterosexual individuals and not often addresses identity-specific stressors relevant to LGBTQ individuals. Emerging adaptations...
Background African Nova Scotians, Indigenous peoples, and refugees experience significant disparities in access to culturally appropriate mental health care due to systemic inequities, intergenerational trauma, stigma, and limited availability of culturally competent services. The Nova Scotia Transcultural Mental Health Program (NSTMHP) was established to close gaps in serving these equity-denied groups using a culturally responsive and collaborative model of care in primary healthcare settings...
Mental Health
Cassidy KL, Ursuliak Z, Holland T, MacDonell KC, Milne R, Daigle P, Johnson S, Sridharan S, Williams O, Sulyman M, Morrison J, Awara M, Natarajan A, Edem D, Agyapong B, Eboreime E, Agyapong VIO•
Introduction The Southeastern region of Nigeria faces a severe public health challenge from hypertension due to its high prevalence. Psychosocial factors including perceived stress, anxiety, depression, coping mechanisms, and social support play essential roles in hypertension development and health behaviour, yet there has been limited scholarly attention to these determinants in Nigerian and international qualitative research. This study addresses this evidence gap by investigating the psycho...
Hypertension
Ebigwei Omeda AR, Chilaka M, Mohammadnezhad M, Vaportzis E•
Background: Dirozalkib is a highly selective anaplastic lymphoma kinase (ALK) inhibitor with intracranial antitumor activity against crizotinib-resistant mutations. This phase III trial evaluated dirozalkib versus crizotinib in patients with ALK inhibitor-naïve, ALK-positive, advanced non-small-cell lung cancer (NSCLC). Methods: In this multicenter, randomized, open-label DIAMOND-2 trial, adult patients with ALK inhibitor-naïve, ALK-positive, advanced NSCLC who either had received no prior syste...
Cancer
Liu Y, Meng X, Yu Y, Chen J, Yang R, Liu L, Zhao Y, Tian R, Li D, Ning R, Li Q, Wu G, Wang L, Duan X, Guo X, Hu Y, Liu W, Liu H•
Background Topological data analysis has had many developments with potential application to precision oncology. The goal of this study is to determine if using geometry-based methods of gene-expression signatures of tumors can be used to both create a definitive classification of responders and non-responders, and to predict patient treatment response using out-of-sample testing methodology. Methods Gene-expression signatures of tumors, constructed from geometrical attributes of data, were c...
Abstract Background Approximately 1 in 100 children worldwide are diagnosed with autism spectrum disorder (ASD), and 46% to 89% of those diagnosed experience significant feeding difficulties. Mobile health (mHealth) apps are a potential tool for scalable support. However, there is nascent literature on the quality and relevance of mHealth apps for managing ASD-related feeding challenges. Objective This study aimed at systematically identifying and reviewing the content, behavior change strat...
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