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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,909–1,920 of 1,994 articles

PubMed

Effects of Acupuncture on Cerebral Blood Flow in Episodic Migraine Patients Investigated by Arterial Spin Labeling MRI.

Objective To investigate the temporal dynamics of cerebral blood flow (CBF) responses to Japanese‐style acupuncture in patients with episodic migraine using arterial spin labeling (ASL) magnetic resonance imaging (MRI) and to compare these responses with those of healthy controls. Methods Patients with episodic migraine were recruited according to the International Classification of Headache Disorders, 3rd edition (ICHD‐3), and healthy volunteers without migraine served as controls. Japanese‐...

Migraine
Kikuchi T, Yamaguchi S, Matsuda H, Tsuchiya K, Araki N•
PubMed

Awareness and Prescribing Patterns of Acute and Preventive Migraine Medications Among General Practitioners: The Kawasaki Medical Association Study.

Aim In Japan, the introduction of anti‐calcitonin gene‐related peptide (CGRP) monoclonal antibodies and the 5‐HT1F receptor agonist lasmiditan has transformed migraine treatment. However, medical consultation and prescription rates for migraine remain low. This study aimed to clarify the awareness and prescribing patterns of acute and preventive migraine medications among physicians in Kawasaki, Japan. Methods A questionnaire survey of 1274 physicians registered with the Kawasaki Medical Asso...

Migraine
Akiyama H, Ono H, Komine Y, Nakano Y, Yamano Y•
PubMed

Iron-Sensitive MRI Reveals Individual Differences in Pain Modulation Rather Than Categorical Markers in Chronic Pain and Migraine.

Objective To determine whether regional iron levels are associated with endogenous pain‐inhibitory function and whether iron‐sensitive MRI techniques, quantitative magnetic susceptibility (QSM) and R2∗ mapping capture differences in midbrain iron content in the globus pallidus (GP), periaqueductal grey (PAG), and red nucleus (RN) across chronic pain (CP), migraineurs (M), and healthy volunteers (HV). Methods Sixty participants (20 CP, 20 M, and 20 HV) underwent a 3T MRI examination. Pain modu...

Migraine
Ydlibi O, Salehi Ravesh M, Bernerth F, Maedler B, Jansen O, Gierthmühlen J, Peters S•
PubMed

Transcranial Photobiomodulation Attenuates Neurogenic Inflammation and Sensory Hypersensitivity in a Nitroglycerin-Induced Migraine Model: Toward a Nonpharmacological Therapy.

Background Migraine is a debilitating neurological condition, characterized by headache, photophobia, and heightened mechanical/thermal sensitivity. Current pharmacological therapies often lead to incomplete relief and adverse effects, necessitating the use of noninvasive alternatives. This study evaluated transcranial photobiomodulation (PBM) in a nitroglycerin (NTG)‐induced migraine model in male mice. Methods Mice were assigned to Sham, NTG, NTG + Sumatriptan (SUMA; 600 µg/kg, s.c.), NTG +...

Migraine
Kazmi S, Vatandoust SM, Athari SZ, Ebrahimian A, Moradi A, Mahmoudi J, Sadigh-Eteghad S, Rajabi M, Akhbari-Shojaei S, Neshan-Alipour R, Nozad A, Hosseinkhani M, Hosseini L, Hamblin MR, Farajdokht F•
PubMed

Body Mass Index Protects Against Temporomandibular Disorders, Whereas Systemic Inflammation, Vitamin D, and Migraine Do Not: A Causal Inference Study.

Background and Objectives Observational studies link temporomandibular disorders (TMDs) with body mass index (BMI), vitamin D, C‐reactive protein (CRP), and migraine but causal relationships remain unclear. This study aimed to assess the bidirectional causal effects between these factors and TMD using Mendelian randomization (MR). Materials and Methods We used publicly available GWAS summary statistics. TMD data were from FinnGen R13 (23,035 cases; 477,151 controls). Exposure data for BMI, vi...

Migraine
Yu M, Dai L•
PubMed

Menopause and Muscle: Closer to Answers, but Significant Questions Remain.

The review by Menzies, Bowtell, Shur and Brook arrives at exactly the right moment [1]. For years, menopause has been framed, sometimes breathlessly, as a musculoskeletal ‘breaking point’ that inevitably triggers rapid skeletal muscle loss. In contrast, this review does something far more valuable. It slows the narrative down, puts human data first and makes a compelling case that our certainty about muscle loss in menopause has outrun the evidence [1]. Their central contribution is not a single...

Menopause
Phillips SM•
PubMed

Retrospective Case Series of Ocular Lyme Disease, 1988-2025.

Reports of ocular manifestations of Lyme disease (LD) are uncommon, and signs and symptoms may be overlooked by physicians. We conducted a retrospective case series of ocular LD reported during 1988–2025. Among 27 published reports in PubMed, we noted that, in 38 cases, the most common ocular manifestation was uveitis, representing 45% of cases, followed by optic neuritis and cranial nerve palsies (including trochlear and abducens). Not all cases met Centers for Disease Control and Prevention su...

Lyme Disease
Bellafiore J, Mahrous A, Gurumurthy V, Capitle E, Schutzer SE•
PubMed

Advancing Diagnostic Accuracy in Liver Cancer: A Systematic Review of Artificial Intelligence Applications in Hepatocellular Carcinoma and Cholangiocarcinoma Detection Using Abdominal CT Imaging.

Objective: This study aimed to systematically evaluate the diagnostic performance of artificial intelligence (AI) in differentiating hepatocellular carcinoma (HCC) from cholangiocarcinoma (CCA) using abdominal CT and MRI, with an emphasis on its clinical implications for liver cancer management. Methods: Following the PRISMA guidelines, we conducted a comprehensive literature search across five major databases (PubMed, Web of Science, ScienceDirect, Scopus, and Google Scholar) from 2000 to Ma...

Liver Cancer
Rattanapitoon SK, Arunsarn P, Meererksom T, Thanchonnang C, Boonsuya A, Phinsiri S, Nomsungnoen P, Pongseeda P, Keeratibharat N, Chansangrat J, Pechdee P, Rattanapitoon NK•
PubMed

Elevated Liver Enzymes and Genotype I of T. gondii Among Liver Cancer Patients: Evidence of a Potential Link.

Objective: Toxoplasma gondii is an intracellular protozoan that may disrupt the traditional cell barriers against cancer, allowing the accumulation of oncogenic mutations over time. Our research aimed to explore the relationship between T. gondii infection and liver cancer development. Methods: The present study, conducted in the city of Nasiriya, Iraq, involved 80 blood samples collected from individuals aged 18 to 70 years, of both sexes. The samples were divided into two groups: 40 from pa...

Liver Cancer
Jasim NH, Al-Waaly ABM•
PubMed

CTH Promotes Liver Cancer Progression and Exploratory Evaluation Supports Enhanced Antitumor Activity of PPG Plus GPC3 CAR-T Cells.

Although hydrogen sulfide (H2S) is a key regulator in cancer biology, the mechanism by which the H2S‐producing enzyme cystathionine‐γ‐lyase (CTH) functions in hepatocellular carcinoma (HCC) remains elusive. Using the slow‐releasing H2S donor GYY4137, we observed enhanced migration and invasion in HuH7 and HepG2 cells. Subsequently, we observed consistent protumorigenic effects of CTH not only in vitro but also in subcutaneous and orthotopic mouse models. Here, our findings suggest that CTH‐H2S s...

Liver Cancer
Guo Y, Yu M, Zhu X, Li W, Liu Y, Wu X•
PubMed

Correction to "Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones".

B. Wang, J. Wei, Q. Huangfu, F. Gao, L. Qin, J. Zhong, J. Wen, Z. Ye, X. Yang, and H. Liu, “Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones,” Oxidative Medicine and Cellular Longevity, 2022, https://doi.org/10.1155/2022/4345037. In the article, the authors have identified an error in which the incorrect number of participants was stated throughout the article. The correct number of participants is 40 controls and 31 kidney stone patients...

Kidney Stones
PubMed

Daridorexant and Insomnia in Clinical Practice: A Nominal Group Technique Consensus Study among Italian Sleep and Insomnia Experts.

Introduction Chronic insomnia disorder significantly affects cognitive, emotional, and physical health. Recently, the dual orexin receptor antagonist (DORA) daridorexant was approved for treating chronic insomnia in several countries. Given the limited evidence available, expert consensus was sought to clarify key clinical issues, inform practice, and guide future research. Methods Thirteen Italian sleep experts employed the Nominal Group Technique (NGT) to identify and rank important clinica...

Insomnia
Ferini-Strambi L, Arnaldi D, Bonanni E, Cicolin A, Gigli GL, Liguori C, Lombardi C, Parrino L, Provini F, Puligheddu M, Romigi A, Silvestri R, Palagini L•

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