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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,921–1,932 of 1,994 articles

PubMed

Psychological Factors, Central Sensitization, and Insomnia as Potential Prognostic Factors for Short-Term Pain and Disability in Patients With Frozen Shoulder: A Multicentric Prospective Single-Cohort Study.

Background Identifying modifiable prognostic factors is essential for personalizing conservative interventions. Several psychological and systemic variables remain underexplored in the frozen shoulder (FS) population, particularly regarding their prognostic relevance for short‐term changes in pain and disability. Aim To estimate the prognostic value of psychological factors, central sensitization, and sleep disturbances in predicting clinical outcomes after 3 months of standardized conservati...

Insomnia
Brindisino F, Silvestri E, Fioretti A, Pulina F, Conteduca J, Navarro Ledesma S, Barbosa GM, Struyf F•
PubMed

Mendelian Randomization Research Examining the Effects of Insomnia on Herpes Zoster and Postherpetic Neuralgia.

Background Insomnia is closely linked to herpes zoster (HZ) and postherpetic neuralgia (PHN); nonetheless, the causal relationship has not been sufficiently clarified. This research employs the Mendelian randomization (MR) method to investigate the causal relationship between insomnia and HZ, as well as PHN. Methods Summary statistics from publicly available GWASs were utilized for four sleep traits (insomnia, sleep duration, habitual short sleep [< 7 h/day], and habitual long sleep [≥ 9 h/da...

Insomnia
Yang X, Li X, Lin J, Chen Y, Zhang X, Zhao Q•
PubMed

High Anemia Awareness Does Not Mitigate Insomnia Risk in Ghanaian University Students: A Cross-Sectional Study.

Background Anemia and insomnia represent significant public health concerns among university students. However, their interrelationship and the potential role of anemia prevention knowledge in mitigating these conditions remain unexplored in Ghanaian tertiary institutions. Aim This study determined the prevalence of anemia and insomnia among Ghanaian university students. Likewise, the knowledge, attitudes, and practices regarding anemia prevention and the association between anemia prevention...

Insomnia
Agyapong L, Apreku JB, Acheampong I, Kpeglo G, Ansaful ONK, Sagoe E, Dadzie CE, Sirbah AC, Yusif MA, Apalebilah S, Owusu G, Donkor DM, Siame D, Boachie J•
PubMed

The association of left atrial volume index and coronary artery disease in type 2 diabetic patients without a history of hypertension and valvular heart disease.

BACKGROUND: Left atrial volume index (LAVI) evaluated using echocardiography serves a powerful predictor of cardiovascular outcomes. Since type 2 diabetes mellitus (T2DM) is a main risk factor for coronary artery disease (CAD), the present investigation was conducted to examine the association between LAVI and incidence of CAD in diabetic patients. METHODS: In this case-control study, 90 type 2 diabetic patients aged 18–70 years who underwent coronary angiography at Imam Hossein Hospital, Teh...

Hypertension
Mahjoob MP, Sadeghi R, Haji Aghajani M, Omidi F, Rostamnezhad M, Salehi M•
PubMed

Efficacy of recombinant growth hormone therapy in children born small for gestational age (SGA): a retrospective analysis.

Introduction Children born small for gestational age (SGA) present with a birth weight or length below –2 standard deviations (SD) relative to population norms for gestational age and sex. In Poland, such patients are eligible for recombinant human growth hormone (rhGH) therapy reimbursed by the National Health Fund. Aim of the study To retrospectively assess the effectiveness of rhGH therapy in children diagnosed with SGA based on clinical data from 39 patients treated with rhGH between 2016...

Hormone
Pałysa A, Kopiec-Burdecka M, Pyrżak B•
PubMed

Sex Hormone-Based Models Outperform Conventional Scores for Metabolic Dysfunction-Associated Steatotic Liver Disease Screening: A Sex-Specific Analysis in Type 2 Diabetes.

Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is highly prevalent among patients with Type 2 diabetes mellitus (T2DM). Although various noninvasive assessment tools for MASLD are currently available, few have been specifically validated in T2DM populations. Furthermore, the role of sex hormones in MASLD and their potential influence on cardiovascular and renal outcomes remain incompletely understood. Methods In this cross‐sectional study of 731 Chinese patients w...

Hormone
Li G, Liu W, Chen R, Guo J, Wang L•
PubMed

Genetics and reproduction in buffalo: latest insights into the genetic architecture of reproductive traits.

Buffaloes are integral to the agricultural economies of numerous countries, providing essential contributions to milk and meat production, as well as draught power. Fertility in buffaloes is a complex quantitative trait that significantly affects both production and economic efficiency. Therefore, elucidating the genetic architecture underlying reproductive traits in buffaloes is critical for the development of sustainable breeding programs aimed at enhancing reproductive performance. This revie...

Genetics
Zhou J, Liu C, Feng W, Deng T, He H, Yang H, Yang L, Liang A•
PubMed

Pompe Disease: A Review of Diagnosis, Molecular Genetics, and Treatment Management.

Introduction Pompe disease, a rare autosomal recessive lysosomal storage disorder, results from mutations in the GAA gene that lead to deficient acid alpha-glucosidase activity and glycogen accumulation in various tissues. Methods This review employs the diagnostic approach to the disease, encompassing enzymatic assays and molecular genetics, with a focus on genotype-phenotype correlations and region-specific mutations. Results Over 500 mutations in the GAA gene, including missense, nonsens...

Genetics
Adadi N, El Brouzi MY•
PubMed

Identifying Novel Biomarkers and Therapeutic Targets for Endometriosis: Integrative Analysis of the Plasma Proteome and Genome.

Background There is currently no consensus on the etiology, pathogenesis, or treatment of endometriosis (EM). The discovery of disease‐associated plasma proteins with causal genetic evidence provides an opportunity to identify new EM biomarkers and therapeutic targets. Methods Protein quantitative trait loci (pQTLs) were derived from plasma proteomic associations in the UK Biobank Pharma Proteomics Project (UKB‐PPP). Genetic associations with EM were obtained from the FinnGen cohort. The asso...

Endometriosis
Zheng J, Yao YL, Chen XZ, Fu LJ, Chi YG, Zhong ZH, Ding YB•
PubMed

Shared Genetic Architecture and Pleiotropic Loci Linking Endometriosis and Inflammatory Bowel Disease: An Integrative GWAS, Colocalization, and Mendelian Randomization Study.

Background Endometriosis (EMS) and inflammatory bowel disease (IBD) are both chronic inflammatory disorders with overlapping clinical features, suggesting a potentially shared etiology. Although epidemiological studies have reported an association between the two conditions, the genetic basis of this relationship remains poorly understood. This study is aimed at characterizing the shared genetic architecture of EMS and IBD, identify pleiotropic loci implicated in both conditions, and explore th...

Endometriosis
Cui X, Wang J, Chen J, Wu H, Liu J, Fang Y, Wan G•
PubMed

Diagnostic Accuracy of the Kissing Ovaries Sign on Transvaginal Ultrasound for Prediction of Bowel Endometriosis in Women with Surgically Confirmed Endometriosis.

Background: Endometriosis is a common gynecological disorder. Non-invasive imaging markers that predict disease severity and bowel involvement are clinically valuable. The purpose of the current study was to evaluate the diagnostic performance of the kissing ovaries (KO) sign on transvaginal ultrasound for predicting bowel endometriosis and advanced disease. Methods: This retrospective diagnostic accuracy study included 252 women with surgically and histopathologically confirmed endometriosis...

Endometriosis
Ahmadbeigi M, Padmehr R, Shadjoo K, Mohammadipour S, Mozzahab A, Gorgin A, Kargar R•
PubMed

Lived Experiences of Endometriosis-Related Pain and Perceptions of a Blended Digital CBT Intervention: A Mixed-Methods Study.

Background Endometriosis affects approximately 10% of women of reproductive age and is associated with reduced health and quality of life yet remains poorly understood and undertreated. The Digital behAvioural HeaLth treatment for chronIc pAin (DAHLIA) aims to enhance behavioural self‐management and resilience to pain through six self‐guided digital modules and regular therapist contact. This study aimed to explore women’s lived experiences of endometriosis‐related pain and their perceptions of...

Endometriosis
Petersson S, Engman L, Carlsson E, Taygar A, Bartels SL, Wicksell RK•

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