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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,933–1,944 of 1,994 articles

PubMed

An Insight on Flavonoids and Flavonoidsincorporated Nano-formulations in the Management of Diabetes Mellitus.

Diabetes mellitus is a worldwide health challenge and imposes a considerable strain on healthcare systems. By 2035, it is anticipated that around 592 million adults will be impacted by diabetes as a result of causes like aging, rapid population expansion, urbanization, obesity, lifestyle modifications, and heightened intake of calorie-dense, fatty, and fast meals. Despite the availability of several pharmaceutical therapies, they often come with higher expenses and adverse side effects, making t...

Diabetes
Patel M, Shah P, Singh S, Prajapati BG•
PubMed

Determination, Validation, and Development of Prediction Scores Related to Hypoglycemia Risk Factors Among Ambulatory Type 2 Diabetes Mellitus Patients in Bali, Indonesia.

Introduction Hypoglycemia is a complication that can disrupt the continuity of therapy for Type 2 Diabetes Mellitus (T2DM) patients. Therefore, ambulatory T2DM patients need supportive treatment to ensure the safety of their medication. Currently, health workers lack a standardized reference for assessing the risk of hypoglycemia in these patients. Therefore, this study aimed to determine, validate, and develop a prediction score of risk factors influencing hypoglycemia in T2DM patients. Metho...

Diabetes
Jaya MKA, Rahmawati F, Yasin NM, Ikawati Z•
PubMed

Beyond Traditional Silos: An Integrated Framework Leveraging Novel Pathways for Reducing Cardio-renal Risk in Type 2 Diabetes.

Diabetes mellitus is a major risk factor for chronic kidney disease (CKD) and accelerates kidney function decline, leading to end-stage renal disease. In addition, patients with CKD are at elevated risk of developing cardiovascular disease with its manifestations as coronary artery disease, heart failure, arrhythmias, and sudden cardiac death through the cardiorenal connection. An online regional and international expert panel of cardiologists, nephrologists, and diabetologists convened in Novem...

Diabetes
Sabbour HM, Hassanein M, Farghaly M, Aljubori HMMS, Attallah NM, Al Rukhaimi M, Al-Ashkar M•
PubMed

The Application of Omics Technologies in Type II Diabetes Mellitus Research.

Diabetes mellitus represents a spectrum of chronic metabolic disorders characterized by elevated blood glucose levels (hyperglycemia), largely due to insulin deficiency or resistance. Type 2 diabetes mellitus (T2DM) is the most prevalent form, accounting for over 90% of diabetes cases globally. Its rising prevalence is a global concern, with projections indicating 783 million cases by 2045. T2DM leads to severe complications, including macrovascular diseases like cardiovascular events and microv...

Diabetes
Al Sultan A, Rattray Z, Rattray NJW•
PubMed

Targeting the Gut Microbiota in the Treatment of Type 2 Diabetes: Dietary Interventions, Microbial Preparations, and Fecal Transplantation.

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disease worldwide, characterized by hyperglycemia and insulin resistance (IR). Its escalating global prevalence and the associated morbidity and mortality render it a major public health concern. Conventional glucose-lowering therapies frequently entail adverse effects, hypoglycaemia risk, and fail to arrest disease progression. Emerging evidence positions the gut microbiota as a central regulator of glucose homeostasis and insulin...

Diabetes
Ding L, Xi Z, Zou Y, Li S, Chen D, Liu Y, Zhao J•
PubMed

Potential Involvement of Fructosylated Human Insulin and Serological Evidence in Subclinical Autoimmune Activity in Type 2 Diabetes Mellitus.

Introduction Type 2 Diabetes Mellitus (T2DM) involves chronic inflammation and recurrent hyperglycemia, often linked to excessive fructose intake. Some patients develop autoantibodies, indicating immune dysfunction. Fructose promotes protein glycation and the formation of Advanced Glycation End-products (AGEs), which may expose novel epitopes recognized as foreign. This study examined the antigenicity of fructosylated human insulin and its impact on lymphocytes in diabetic patients. Methods F...

Diabetes
Raza A, Habib S, Noor S, Ahmad R, Chandni M, Moinuddin, Mahmood R, Rahaman PF, Ahmad A•
PubMed

Reported Prevalence and Associated Factors of PTSD and Posttraumatic Stress Symptoms Among Individuals With Diabetes: A Scoping Review.

Background Posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) may occur among individuals with diabetes, but reported estimates and associated factors vary considerably across studies. This scoping review is aimed at mapping the reported prevalence of PTSD/PTSS and factors associated with these outcomes among individuals with diabetes. Methods A scoping review was conducted in accordance with the PRISMA‐ScR guidelines. Web of Science, PubMed, Embase, Cochrane Librar...

Diabetes
Yuanping Z, Ruiqing C, Xiong K, Yuanyuan J•
PubMed

Electroacupuncture May Alleviate Depression and Exerts Anti-Inflammatory Effects Through IDO1 Modulation of the Kynurenine Pathway.

Background Depression is one of the most common mental health conditions worldwide. Numerous studies have identified various factors associated with the onset of depression. Among these factors, inflammation is a key contributor. During the inflammatory process, pro‐inflammatory cytokines activate indole‐2,3‐dioxygenase (IDO), which converts tryptophan (TRP) to kynurenine (KYN) via the KYN pathway (KP). This increases the production of neurotoxic byproducts, thereby exacerbating depressive symp...

Depression
Chen B, Wu X, Ying X, Zhang J, Jiang S, Di Z, Chen Y, Huang Y, Chang H, Ma R, Guo Q•
PubMed

Nonlinear Relationship of Weight-Adjusted Waist Index With Self-Reported Trouble Sleeping and the Mediating Role of Depression.

Purpose The weight‐adjusted waist index (WWI) is a novel measure for obesity that appears to outperform body mass index (BMI) and waist circumference (WC) in assessing lean and fat mass. Our aim was to explore the possible link between WWI and trouble sleeping. Methods This cross‐sectional study included 30,999 adults who participated in the National Health and Nutrition Examination Survey (NHANES) database. The WWI was calculated as WC (cm) divided by the square root of weight (kg). Trouble...

Depression
Song Y, Wang Z, Shao X, Zhong S•
PubMed

Mortality Trends in Patients Aged 25 and Older With Comorbid COPD and Diabetes Mellitus in the United States: A CDC WONDER Database Study From 2000 to 2023.

Introduction Diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD) are among the leading chronic diseases that significantly impact global morbidity and mortality. Growing evidence indicates a bidirectional interplay between metabolic and pulmonary dysfunction. This study aims to identify the demographic and regional trends of DM and COPD‐related mortality in the United States from 2000 to 2023. Methodology DM‐ and COPD‐related deaths in the United States from 2000 to 2023 w...

Copd
Ahmed M, Fatima S, Shafiq SB, Mansoor KT, Aqsa F, Naveed MA, Ali A, Sandhyavenu H, Qureshi B, Neppala S•
PubMed

Prevalence of Cardiovascular Diseases in COPD-OSA Overlap Syndrome Versus COPD Alone: A Systematic Review.

Background Chronic obstructive pulmonary disease (COPD) is frequently associated with cardiovascular comorbidities. Obstructive sleep apnea (OSA) may coexist with COPD, forming the so‐called overlap syndrome (OS), and may further increase cardiovascular risk through intermittent hypoxia, systemic inflammation, and sympathetic activation. This systematic review is aimed at synthesizing and comparing the burden of cardiovascular comorbidities in patients with COPD and coexisting OSA versus those...

Copd
Oprea ȘF, Dumitrache-Rujinski Ș, Diaconu CC•
PubMed

Adjunctive Short-Wave Diathermy to High-Frequency Chest Wall Oscillation for Acute Exacerbation of COPD: A Randomized Controlled Trial.

Objective This study aimed to evaluate the efficacy and safety of combining short‐wave diathermy (SWD) with high‐frequency chest wall oscillation (HFCWO) compared with HFCWO alone and routine treatment in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods This single‐center, parallel‐group randomized controlled trial enrolled 89 patients with AECOPD admitted to Yongkang First People’s Hospital between March 2024 and March 2025. Participants...

Copd
Li Q, Sun J, Ying L, Ying Z•

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