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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,945–1,956 of 1,994 articles

PubMed

The Role of Melatonin in Smoking Cessation and COPD Management: A Randomized Controlled Trial.

Background Chronic obstructive pulmonary disease (COPD) is a leading global health concern, characterized by persistent airflow obstruction and a significant burden on quality of life. Smoking cessation is critical for COPD management, but nicotine addiction poses challenges. Emerging evidence suggests that melatonin may aid in addiction management, though its efficacy in COPD remains underexplored. Methods This randomized, triple‐blind, controlled clinical trial evaluated the impact of melat...

Copd
Gholinataj Jelodar M, Haddad N, Hoseinzadeh F, Mirzaei S, Sahebnasagh A, Ramezani V, Mohammadi MH, Saghafi F•
PubMed

Critical Errors in Inhaler Technique Among Patients With Asthma and COPD: A Cross-Sectional Study in a Real-World Setting.

Background The correct use of inhalation devices is essential for achieving adequate control of asthma and COPD; however, critical errors in inhalation technique are frequent and substantially reduce treatment effectiveness. This study’s objective was to evaluate the prevalence of inadequate inhalation technique among patients with asthma and COPD and to identify the most common critical errors and the factors associated with incorrect use. Methods This cross‐sectional observational study inc...

Copd
Damasceno IHM, Oliveira RJF, Neves SJF, Martins RR, Diniz RDS•
PubMed

Neutrophil to High-Density Lipoprotein Cholesterol Ratio and All-Cause Mortality Among Asthmatic Individuals: A Cohort Study.

Background At present, there is no epidemiological study available to confirm the efficacy of neutrophil to high‐density lipoprotein cholesterol ratio (NHR) in assessing the prognosis of the asthma population. This study aims to investigate the value of NHR in assessing the prognosis of asthma patients by utilizing data from National Health and Nutrition Examination Survey (NHANES) and constructing the predictive models. Methods This study used Cox regression models, cumulative risk curves, a...

Cholesterol
Li D, Luo C, Xia J•
PubMed

Linderae Radix Attenuates Hyperlipidemia by Regulating Reverse Cholesterol Transport through the miR-33-PPARα/LXRα Axis.

Introduction It has been reported that miR-33 could down-regulate the key protein expression of reverse cholesterol transport (RCT) to clear excess cholesterol. Our previous studies reported that Linderae Radix (Wuyao in Chinese, WY) has a strong anti-hyperlipidemia effect by regulating RCT, but whether the regulation of WY on RCT is related to miR-33 remains unclear. Methods In in vivo research, mice were randomly divided into five groups. miR-33 agomir was administered to hyperlipidemic (HL...

Cholesterol
Ye H, Lai W, Lei S, Zhang J, Li K, Wang Z, Zheng X, Yang X, Lou Z•
PubMed

Circulating Levels of Remnant Cholesterol as Potential Biomarkers for Predicting Gestational Diabetes: A Systematic Review.

Objectives Gestational diabetes mellitus (GDM) is a common pregnancy complication with serious consequences for both mother and child. Current diagnostic methods are invasive and limited. The present study was conducted to evaluate circulating remnant cholesterol (RC) as a potential predictive and diagnostic biomarker for GDM. Methods The present study was conducted following PRISMA guidelines. Databases including Scopus, PubMed, Web of Science (WoS), Embase, ProQuest, Cochrane, and Google Sc...

Cholesterol
Abdi F, Rahnemaei FA, Khosravani F, Sadri F, Mohammadi Y•
PubMed

Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer's Disease.

Cholesterol transport within the brain represents a highly regulated process essential for maintaining neuronal function and central nervous system (CNS) homeostasis. Unlike peripheral tissues, the brain relies on in situ cholesterol synthesis, primarily by astrocytes and other glial cells, which supply neurons via high-density lipoprotein (HDL)-like particles, identified in the human cerebrospinal fluid (CSF). The major component of HDL-like lipoproteins is the apolipoprotein E (ApoE), whose E4...

Cholesterol
Ugolotti M, Papotti B, Trentini A, Mola G, Cervellati C, Adorni MP, Zimetti F•
PubMed

The Association between Remnant Cholesterol Levels and Computed Tomography-based Low Bone Mass, Low Muscle Mass, and Osteosarcopenia in Older Adults.

Objective The associations between remnant cholesterol (RC) and low bone mass and sarcopenia have not been well studied. This study aimed to demonstrate the link between serum RC and the prevalence of low bone mass, low muscle mass, and osteosarcopenia in older adults. Methods This retrospective study involved 1995 individuals aged 50 and above who received CT scans for lung cancer screening from 2016 to 2020. Remnant cholesterol (RC) was calculated as follows: total cholesterol (TC) - (low-d...

Cholesterol
Wang R, Wang Y, Liu J, Wei Z, Tang H, Chen X•
PubMed

Feasibility of Predicting the Triglyceride/High-Density Lipoprotein Cholesterol Ratio using Spectral Imaging with a Multi-Material Decomposition Technique on Fast kVp-Switching Dual-Energy CT.

Introduction/Background Non-alcoholic fatty liver disease (NAFLD) is closely associated with increased cardiovascular risk, and the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is a reliable predictor of cardiometabolic disorders. Dual-energy CT with Multi-Material Decomposition (MMD) enables non-invasive quantification of liver Fat Fraction (FF), but its value in predicting TG/HDL-C ratio remains unexplored. To investigate the correlation between the triglyceride/high-den...

Cholesterol
Xie A, Wang C, Huang S, Zhang J, Zhu L, Zhou J•
PubMed

The Effects of Neonatal Zingerone Administration and Adolescent Alcohol Exposure on Bone Health Markers and Morphometry in Male Sprague-Dawley Rats.

Objective Neonatal interventions influence long‐term developmental outcomes, with excessive alcohol consumption impairing metabolism and bone health. Zingerone, a natural antioxidant, may possess health benefits against alcohol‐induced oxidative damage and inflammation, promoting bone health. This study investigates the effects of zingerone on markers of bone turnover and morphometry in neonatal rats subjected to alcohol exposure during critical developmental stages. Methods Ten‐day‐old male...

Bone Health
De Vos B, Asiedu B, Joubert AM, Kasonga AE, Nyakudya TT•
PubMed

Selenium Enhances Osteogenic Differentiation and Mineralization in Human Osteoblasts: Implications for Bone Health and Metabolism.

Introduction Sodium Selenite (NaSe) is a molecule with various biological activities. Bone fractures and osteoporotic diseases are increasingly common health issues, prompting the search for alternative treatments. Therefore, the purpose of this study was to examine the antioxidant and osteogenic properties of NaSe. Methods The experiments were conducted using the hFOB1.19 osteoblast cell line. The MTT assay was used to assess the effects of NaSe on cell viability, while cytotoxicity was eval...

Bone Health
Sahin E, Arafat M, Koparal AT•
PubMed

The Burden, Risk Factor Analysis, and Prediction of Low Back Pain in China From 1990 to 2021.

Introduction The burden of low back pain (LBP) in China poses a substantial public health challenge. This study aimed to analyze longitudinal trends in the burden of LBP and its associated risk factors based on data from the Global Burden of Disease (GBD) 2021 study and to project future trends. Methods Epidemiological data for LBP in China and globally were retrieved from the GBD 2021 database. Disease burden was characterized using summary tables and age‐dependent line graphs. Joinpoint reg...

Back Pain
Lin A, Ma Y, Zhang C, Yang W, Han S, Zhang H, Liu Z, Tang S, Gong W, Ma X•
PubMed

Comparing VR-Based Exercises and Routine Physical Therapy Effects on Pain, Kinesiophobia, and Functional Abilities in Non-Specific Chronic Low Back Pain Patients "A Randomized Clinical Trial".

Objectives: To compare the effects of Virtual Reality (VR)-based exercises and routine physical therapy on pain, kinesiophobia, and functional abilities in patients with Non-Specific Chronic Low Back Pain (NSCLBP). Methods: Twenty-eight participants aged 20 to 55 were included and randomly assigned to two groups, ensuring single blinding. Both groups received routine physical therapy, which included transcutaneous electrical nerve stimulation (TENS), ultrasound therapy, and infrared light, al...

Back Pain
Khalifeh F, Karimi N, Mohammadi S, Azarsa MH, Hosseinzade S, Behzadipour S, Masoudi P•

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