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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,981–1,992 of 1,994 articles

PubMed

Headache Frequency and Depressive Symptoms Are Independently Associated With Disability in Migraine: A Large-Scale, Cross-Sectional Study.

Objective The burden of migraine is influenced by a complex interplay of headache characteristics, psychiatric comorbidities, and sleep disturbances. This study aimed to examine factors independently associated with migraine‐related disability and severe functional impairment in a large clinical cohort. Methods This cross‐sectional study included 1186 patients diagnosed with migraine according to ICHD‐3 criteria. We collected data on demographics, headache characteristics (monthly headache da...

Migraine And Headache
Pu Y, Deng D, Yao Y, Hong F, Zheng Y, Mao M•
PubMed

Letter to the Editor regarding: "Lipid-lowering therapy in patients with hypercholesterolemia in terms of the POLSCORE and SCORE2 scales. A single-center retrospective analysis".

I read with great interest the study by Rogozik et al. [1], which demonstrated that cardiovascular risk assessed using SCORE2 was substantially higher than that estimated with Pol-SCORE in patients with hypercholesterolemia without established cardiovascular disease. Through risk reclassification and comparisons of treatment status between the two scoring systems, the authors further showed that many individuals classified as high or very high risk by SCORE2 were discharged without lipid-lowerin...

Scales
Kimura R•
PubMed

Unraveling the Pathogenetic Potential and Immune Crosstalk of Yersinia spp. in Inflammatory Bowel Disease.

Yersinia enterocolitica and Yersinia pseudotuberculosis have been identified as microbiological factors in the multifactorial pathophysiology of inflammatory bowel disease (IBD). Although conventionally associated with self‐limiting gastroenteritis, Yersinia has been increasingly investigated for its potential role in IBD, particularly in genetically predisposed individuals. Whether this reflects causality, opportunistic colonization, or secondary enrichment within inflamed tissue, however, rema...

Inflammatory Bowel Disease
Sabzehali F, Zerbato V, Bella SD, Morabito S, Zali MR, Yadegar A•
PubMed

Association Between Inflammatory Bowel Disease and Venous Leg Ulcers: Insight From Mendelian Randomization Analyses.

Background This study aimed to investigate the potential causal relationship between inflammatory bowel disease (IBD) and venous leg ulcers (VLU) using Mendelian randomization (MR). Materials and Methods Independent genetic variants for IBD and VLU were selected as instruments from previously published genome‐wide association studies (GWAS) in people of primarily European descent. MR analyses were carried out utilizing inverse‐variance weighted (IVW), weighted median, MR Egger, simple mode, a...

Inflammatory Bowel Disease
Lin Y, Qin X, Zhang H, Huang J•
PubMed

Optimising Blood Test Monitoring Frequency for Inflammatory Bowel Disease Patients: Balancing Adherence, Comfort and Risk.

Background Inflammatory bowel disease (IBD) therapies can cause myelosuppression and hepatitis. The European Crohn’s and Colitis Organisation (ECCO) recommends 3‐monthly blood test monitoring; however, these recommendations are largely based on expert consensus, and real‐world evidence informing optimal long‐term monitoring intervals remains limited. Aim To determine the incidence of medication‐related hepatitis and myelosuppression in a population‐based IBD cohort and estimate the laboratory...

Inflammatory Bowel Disease
Ravikulan A, Irwin J•
PubMed

Exploring the Comorbidity Mechanism among Functional Diarrhea, Irritable Bowel Syndrome with Predominant Diarrhea, and Functional Dyspepsia through the Gut-brain Axis and the Pharmacological Mechanisms of Shen-Ling-Bai-Zhu-San Therapy.

Background Functional Diarrhea (FDr), Irritable Bowel Syndrome with predominant diarrhea (IBS-D), and Functional Dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) with significant impacts on quality of life. While the gut-brain axis and key regulators like 5-hydroxytryptamine (5-HT), dopamine (DA), and butyrate are known to play crucial roles in these conditions, the mechanisms underlying their comorbidities remain unclear. Shen-Ling-Bai-Zhu-San (SLBZS), a traditional herb...

Diarrhea And Irritable Bowel
Mei CF, Han LL, Xue H•
PubMed

Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology.

ABSTRACT Background Melasma is a chronic, relapsing hyperpigmentation disorder driven by complex interactions among genetic predisposition, hormonal fluctuations, UV exposure, oxidative stress, inflammation, and photoaging. Its psychosocial impact is substantial, especially among women with darker skin types, and treatment remains challenging due to its multifactorial pathogenesis and high recurrence rates. Aims This review aims to synthesize current knowledge on melasma pathophysiology, hig...

Cosmetic Dermatology
Liao T, Luo R, Deng Y, Yang H, Du Y•
PubMed

Next-Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy.

Immunotherapy has reshaped the oncology landscape by enabling the immune system to recognize and eliminate malignant cells. Although immune checkpoint inhibitors (ICIs) targeting cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4), programmed cell death‐1 (PD‐1), and programmed death‐ligand 1 (PD‐L1) have achieved durable responses in several cancers, their therapeutic benefit remains limited to a subset of patients, largely due to immune evasion, tumor heterogeneity, and immunosuppressive feat...

Cancer Immunotherapy
Bautista J, Echeverría CE, Maldonado-Noboa I, Adatty-Molina J, Suárez Urresta S, Coral-Riofrio EC, Araujo-Abad S, Kyriakidis NC, López-Cortés A•
PubMed

Comparative analysis of second and third-generation nanobody-based CAR-NK cells targeting PSMA in prostate cancer immunotherapy: In silico and in vitro studies.

Objective(s): The use of CAR technology in the treatment of cancer cells is progressing, as well as the use of CAR T-cell in the treatment of blood malignancies is in the clinical trial stage. In this study, have compared the second and third generation CAR expressed in NK cells in dealing with prostate cancer cells. Materials and Methods: To optimize the CAR design for detection of NK-92 cells, an in silico approach to select between two tags (Flag and c-Myc tags) was initially employed, ult...

Cancer Immunotherapy
Gandomkar Ghalhar M, Karami Vandishi A, Ramazani A, Hajari Taheri F, Sharifzadeh Z, Abolhassani M, Soleimani M, Taghipour N, van Weerden WM, Bandehpour M, Hassani M, Bagherzadeh K•
PubMed

Resveratrol as an immune checkpoint inhibitor to enhance the efficacy of breast cancer immunotherapy.

A major goal in cancer treatment is to convert “cold” tumors into “hot” ones by altering the tumor microenvironment (TME). Breast cancer is often a cold tumor and is resistant to immunotherapy. Resveratrol is a polyphenolic compound found in grapes, with antioxidant, anti-inflammatory, and potential cardioprotective and anti-aging properties. Resveratrol promotes the conversion of immunologically cold breast tumors into hot tumors, thereby increasing the efficacy of immunotherapy. This article r...

Cancer Immunotherapy
Alamolhodaei NS, Hudson BI, Mosaffa F, Boozari M•
PubMed

Double Q-Learning for Intelligent Multi-Drug Scheduling in Cancer Chemotherapy Optimisation.

ABSTRACT Chemotherapy scheduling poses a challenging control problem due to the need to suppress tumour growth whilst maintaining systemic toxicity within clinically acceptable limits. This study develops a double Q‐learning–based controller for optimising daily dosing of a three‐drug regimen consisting of cisplatin, docetaxel and irinotecan. A pharmacokinetics–pharmacodynamics (PK/PD) tumour model with eight resistance states is used as the simulation environment. The controller aims to minimi...

Cancer Chemotherapy
Alizade B, Hajipour A•
PubMed

Benign Growth, Malignant Protection? Insights into Benign Prostatic Hyperplasia and Prostate Cancer.

We read with great interest the recent review by Zarakowska et al [1] on the relationship between prostate cancer (PCa) and benign prostatic hyperplasia (BPH), which thoughtfully explores the roles of inflammation, oxidative stress, and epigenetics as common pathogenic links. The authors correctly highlight that chronic inflammation is a key factor in both conditions and cite epidemiological evidence suggesting that a diagnosis of BPH is associated with an increased risk of PCa incidence and mor...

Benign Prostatic Hyperplasia
Su PJ, Shao IH, Lin YH•

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