Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated destruction of the myelin sheath in the central nervous system. In this work, we develop and analyze a mathematical model describing the interactions among myelin, autoreactive immune cells, regulatory immune cells, and treatment. A fast-time reduction of the slow–fast model yields an analytically tractable immune subsystem that captures the principal immune interactions. We establish the existence and stabi...
Following the publication of this article [ 1 ], the corresponding author requested a correction to Fig 6C and 6D, after concerns were raised about unusually repetitive features appearing in these panels. The corresponding author stated that internal microscope-generated labels were removed from the Fig 6C and 6D image by covering the labelled areas with a portion of the adjacent image. They provided what they described as an original unedited image underlying Fig 6D, and a re-stained and reimag...
Abstract From 2017 to 2021, the American Society of Hematology (ASH) conducted the largest study to date of the hematology workforce in the United States. The study highlighted a deficit in the classical hematology (CH) workforce. Despite the very high CH clinical volumes encountered by practicing hematologists and medical oncologists, <5% of all hematology and medical oncology fellows reported having a career focus in CH. The reason underlying this deficit was a lack of mentorship in CH compar...
Hematology
Lee AI, Masselink LE, Naik RP, Carraway H, Connell NT, DeCastro LM, Dent GA, DiMichele D, Ellis L, Leon AG, Loren AW, Lucas TL, Marshall AL, Mims M, Nelson M, Nagalla S, O'Connell C, Park SJ, Rajasekhar A, Sharma D, Smith M, Weeks LD, Wun T, Fritz J, Reynolds R, Van Havre N, Erikson CE•
Background Iron deficiency is the most common micronutrient deficiency and, when untreated, progresses to anemia. Existing guidance on the diagnostic criteria for iron deficiency is limited and not evidence based. Objective These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about the diagnosis of iron deficiency, taking a global perspective in all settings. Methods A...
Hematology
Powers JM, Lim MY, Achebe MO, Akpan IJ, Auerbach M, Brown MC, Cardenas MP, Cromwell C, DeLoughery T, Fleming RE, Fraga M, Goshua G, James P, Lewkowitz A, May J, Nnadozie G, Ogunnaya F, Ruiz-Arguelles GJ, Sholzberg M, Van Doren L, Weyand AC, Zeller MP, Azzam M, Choaib A, Hamarsha Q, Kawtharany H, Khawandi J, Mustafa RA•
Abstract Study Objectives To predict the improvement in sleepiness following continuous positive airway pressure treatment for obstructive sleep apnea using baseline characteristics. Materials and Methods Data from five polysomnography cohorts (HomePAP, BestAIR, ABC, STAGES, and MESA; total n = 2332) were analyzed. Associations between polysomnographic metrics and Epworth Sleepiness Scale were assessed using multivariable linear regression. Cross-validated Least Absolute Shrinkage and Select...
Sleep Apnea
Staykov E, Töyräs J, Mann DL, Leppänen T, Kainulainen S, Azarbarzin A, Sands SA, Terrill PI•
Abstract Purpose To identify and evaluate cardiovascular outcome trials for glucagon-like peptide-1 receptor agonists (GLP1RAs) in various patient populations, including those with or without type 2 diabetes (T2D). Summary A systematic search of MEDLINE identified 12 cardiovascular outcome-based randomized controlled trials: 10 in patients with T2D, one in patients with overweight/obesity and atherosclerotic cardiovascular disease (ASCVD) but not T2D, and one in patients with obesity and hea...
Abstract An estimated 60% of autistic adults suffer from insomnia symptoms, which significantly impairs daily functioning and wellbeing. This study evaluated the effectiveness of i-Sleep Autism, a 5-week, guided self-help internet-delivered cognitive behavioral therapy-based intervention (ICBT-I) for insomnia in autistic adults. In co-creation with seven autistic adults with sleeping problems, i-Sleep Autism was adapted from i-Sleep, a pre-existing non-autism specific intervention. A total of 1...
Abstract Purpose To assess the comprehensive workflow and time and motion activities associated with hospital pharmacy and nursing staff for a cephalosporin antibiotic in 3 different marketed formulations: (1) a formulation prepared by traditional compounding, (2) a dual-chamber IV bag stored with prefilled diluent in the upper chamber and powdered drug in the lower chamber, and (3) a standard diluent container with an integrated drug vial adaptor that allows for drug admixture after connectio...
Antibiotic
Patel AN, Curtin CR, Ortiz K, Valencia D, Martin R, Runge M, Wicks J•
SUMMARY OBJECTIVE: Gestational diabetes mellitus is characterized by metabolic dysfunction and altered inflammatory signaling. The aim of this study was to evaluate maternal serum oncostatin M levels in pregnancies complicated by gestational diabetes mellitus and explore their associations with metabolic and pregnancy outcomes. METHODS: In this prospective case–control study, 40 women with gestational diabetes mellitus and 40 healthy pregnant controls were enrolled. Maternal serum oncostatin...
Lumbar facet arthropathy is a common diagnosis that directly correlates with age and is a condition with no formal treatment. A 46‐year‐old female with chronic right lower back and buttock pain has CT scans which revealed right L4–L5 and L5–S1 facet joint arthrosis. After the patient received two radiofrequency ablation procedures, with the latter being less effective than the first, the patient′s pain was still present. Because of persistent pain, cryoneurolysis was proposed as an alternative i...
Pain
Kim J, Hui BE•
Stay current
Healthcare information curated for you.
Register to unlock a wealth of healthcare information and medical resources tailored to your healthcare profession.
Cookies on POR. Essential cookies keep the site working. With your permission, optional analytics cookies help us understand how the site is used. We do not send your POR account identity to Google. Read the privacy policy.
