Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Under the pressures of climate change, floods and droughts are increasingly challenging global water systems, requiring transformative approaches for the integrated and adaptive management of water-resilient river landscapes. Enhancing landscape “sponge functioning”, the capacity to intercept, retain, store, and release water, is increasingly promoted, yet guidance remains fragmented between local measures and landscape-scale strategies, limiting the coordinated prioritization and implementation...
Scales
Gebker M, King P, Gottwald S, Vinke-de Kruijf J, Ruangpan L, Penning E, Wentling K, Albert C•
Study objectives Despite representing a highly prevalent comorbidity, standard screening tools for obstructive sleep apnea (OSA) lack validation in the hypertrophic cardiomyopathy (HCM) population. We sought to prospectively evaluate the diagnostic accuracy of three widely used screening tools against gold-standard polysomnography in an HCM cohort and to explore the potential for a tailored predictive model. Methods In this prospective cohort study, patients with HCM completed the Epworth Sle...
Sleep Apnea
Karim S, Iyyappan BS, Tabraiz S, Rajendran A, Chahal A, Geske JB, Chamberlain AM, Somers VK•
Abstract Asthma exacerbation can be triggered by various forms of air pollution, including PM2.5 from wildfire smoke. This study aims to investigate the association between wildfire smoke PM2.5 exposure and asthma exacerbations in adults during the warm months (April–August) between 2006 and 2019. Using a case‐crossover design, we analyzed 18,935 asthma exacerbation events and four matched control periods per event from the National Institutes of Health (NIH) All of Us research program. We used...
Asthma
Huang Y, Luo L, Leng S, Zhang S, Lavin RP, Buenemann M, Lin Y, Campen M, Gong X•
Clarifying the patterns of neural activation during fear extinction in anxiety disorders (ADs) is essential for advancing our understanding of inhibitory learning. However, the underlying mechanisms remain poorly characterized in large, heterogeneous cohorts of patients. Utilizing a delayed fear extinction fMRI paradigm, this study examined neural responses in 280 patients with ADs — comprising panic disorder, agoraphobia, panic disorder with agoraphobia, social anxiety disorder, and multiple sp...
Anxiety
Qian Z, Yang Y, Richter J, Domschke K, Koelkebeck K, Deckert J, Herrmann MJ, Plag J, Ströhle A, Wittchen HU, Pittig A, Hamm A, Arolt V, Dannlowski U, Schneider S, Margraf J, Rief W, Lueken U, Kircher T, Ridderbusch IC, Straube B•
Introduction Adolescence represents a period of heightened vulnerability for the initiation of psychoactive substance use, such as cannabis. A growing body of research suggests a marked co-occurrence between attention-deficit/hyperactivity disorder (ADHD) symptoms and early or problematic cannabis use. However, most of these studies are cross-sectional, raising questions about the nature and directionality of this association. Understanding the underlying dynamics of this relationship is of par...
Adhd
Girard-Lapointe J, Castellanos-Ryan N, Lynch SJ, Watts JJ, Didaskalou M, Conrod PJ•
ABSTRACT Mixed connective tissue disease is a multisystem autoimmune condition characterized by overlapping clinical and serological features related to anti‐U1‐RNP antibodies of at least two connective tissue diseases. It may present with myocarditis, pericarditis, pulmonary arterial hypertension, and, less commonly, heart failure. We present a 21‐year‐old female with bilateral foot swelling, cough, and shortness of breath 3 months after a vaginal delivery. On examination, she was hypotensive...
Hypertension
Alla SSM, Khetan MS, Alla D, Ganguru SL, Appala S, Sree K, Shah RJ, Seth A, Rawtani NA, Aamir MR, Emmanuel NW•
Objective To compare pregnancy and neonatal outcomes following fresh high-quality single blastocyst transfer (SBT) across different maternal age groups. Methods This retrospective cohort study included 4352 women who underwent fresh high-quality SBT and were divided into three age groups: <30 years (Group A, n = 1939), 30–34 years (Group B, n = 1801), and 35–37 years (Group C, n = 612). Baseline characteristics, pregnancy outcomes, and neonatal outcomes were compared across the groups. Non-li...
Background Self-confidence and anxiety are key emotional determinants of clinical decision-making (CDM) among nursing students, yet evidence on interventions that address both during actual clinical placements in resource-limited settings remains limited. Objective This study examined the changes in self-confidence and anxiety in CDM among undergraduate nursing students in Malawi during Case-Based Learning (CBL) with post-clinical debriefing and reflection, and whether patterns of change diff...
Objective This three-arm randomized controlled trial aimed to investigate the comparative clinical effects of Tai Chi (TC), Baduanjin(BDJ), and Health Education(HE) for controlling symptoms and restoring physical function in individuals diagnosed with knee osteoarthritis(KOA). Methods This randomized controlled trial was conducted on patients with KOA, who were randomly allocated 1:1:1 to three groups (40 participants per group, total randomized n=120): TC, BDJ, or HE. The study lasted 48 wee...
Background Adults with atopic dermatitis frequently make treatment-related decisions about symptom management, treatment, self-care, and relapse prevention, but how these decisions unfold across the course of a chronic and relapsing disease remains insufficiently understood. Objective To map the treatment decision-making journey of adults with atopic dermatitis and identify stage-specific support needs from the patient perspective. Methods A descriptive qualitative study was carried out in...
Background This study explored the correlation of the junctional zone, depth of myometrial invasion (DMI), and their combination (COJD) with symptom recurrence after ultrasound-guided high-intensity focused ultrasound ablation surgery (FUAS) in patients diagnosed with intrinsic adenomyosis. Methods A total of 326 patients undergoing FUAS between June 2017 and March 2024 were enrolled in this retrospective analysis. Symptom recurrence was defined as the return of menorrhagia or dysmenorrhea af...
Ultrasound
Jiang ZJ, Wu J, Zhang Y, Shen LM, Chen WQ, Zhang X, Luo QM, Lv FJ, Tang Y•
Purpose Robotic-assisted gait training (RAGT) offers a technology-driven approach to support intensive rehabilitation and recovery following disabling stroke. This study evaluates clinical feasibility, safety surveillance, and descriptive within-stay functional changes in an inpatient cohort receiving the Rise&Walk® (end-effector RAGT [E-RAGT] device, donated by the manufacturer, Healing Innovations, Inc.) alongside standard physical therapy. Patients and Methods In this single-cohort, retros...
Stroke
Hartman J, Benda L, Costantine J, Fant S•
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