Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Background Right heart catheterization (RHC) is the reference standard for diagnosing pulmonary hypertension (PH), whereas echocardiography is the primary noninvasive tool for identifying patients who require further evaluation. Whether electrocardiography (ECG) and natriuretic peptides provide incremental diagnostic information beyond echocardiographic assessment in patients referred for RHC remains uncertain. Methods This single-center retrospective study included 130 hospitalized patients...
Background Acute appendicitis is the most common surgical problem encountered during pregnancy. Our case series was conducted to evaluate the clinical presentation, diagnosis, management, and outcomes of acute appendicitis in pregnant women. Methods A retrospective analysis of nine pregnant women diagnosed with acute appendicitis at James Cook University Hospital, United Kingdom, from 2017 to 2024 was conducted. Patients were evaluated according to age, clinical presentation, gestational age,...
Purpose To determine whether perimenopausal women receiving menopausal hormone therapy (MHT) have decreased odds of developing soft‐tissue shoulder disorders compared with women without an active MHT prescription, specifically adhesive capsulitis, bursitis, bicipital tendinitis, calcific tendinitis, atraumatic rotator cuff tear/rupture, and shoulder impingement syndrome and to quantify the impact of differing formulations and administration route. Methods The TriNetX US Collaborative Research...
Hormone
Shah IK, Shah AK, Burkhart RJ, Dannacher CA, Desai NN, Calcei JG, Campbell AL•
The rapid development of artificial intelligence (AI) is transforming modern society including animal genetics and breeding which is essential for meeting global nutritional needs in supplying milk, meat, and eggs among the most complete sources of protein and micronutrients. Although animal breeding has a long history of using data-driven prediction methods, the application of modern AI approaches remains at a relatively early stage and shows substantial potential for wide-ranging applications...
Genetics
Zhu D, Wells A, Stephansen RB, Cheng H, Lassen J, Banos G, Coffey M, Fang L, Li B•
ABSTRACT Ubiquitin‐like with PHD and RING finger domains 1 (UHRF1) is an epigenetic regulator with oncogenic activity, but its role in PARP1 protein homeostasis in ovarian cancer remains unclear. We assessed UHRF1 expression in public datasets and clinical specimens, tested UHRF1 depletion in ovarian cancer cells and mouse models, and examined UHRF1–PARP1 association, protein turnover, ubiquitination, and rescue. UHRF1 was elevated in ovarian tumor samples, and high expression was associated wi...
Cancer
Chen Y, Wu L, Kang J, Xu H, Ling Q, Yang S, Sun T, Lai H, Tan H, Yang G, He W•
ABSTRACT Asthma and sickle cell trait (SCT) are common conditions in adolescents and do not usually preclude high‐level athletic participation. Both may be associated with exertional symptoms, creating diagnostic uncertainty and management challenges in athletes. We report the case of a 17‐year‐old football player with asthma and SCT who presented with exertional dyspnoea and muscle cramps. Routine investigations, including lung function tests, chest imaging and echocardiography, were within no...
ABSTRACT Macrophage activation syndrome (MAS) can complicate systemic juvenile idiopathic arthritis (sJIA) evolving over weeks. With SARS‐CoV‐2 positivity and coronary dilation, MIS‐C cannot be excluded, and here the timeline and serology do not establish SARS‐CoV‐2 as the trigger. Fibrinogen is an acute‐phase reactant and should not be required to recognize MAS.
Abstract Background and Aims Multiple advanced therapies are available for the treatment of Crohn’s disease (CD). Treatment patterns in newly diagnosed patients and the factors associated with persistence remain unclear. We present interim results of the iCREST-CD registry describing treatment patterns and persistence with advanced therapies. Methods Patients aged ≥16 years with newly diagnosed CD and who had no prior exposure to advanced therapies were enrolled. Persistence of advanced ther...
Crohn's Disease
Shinzaki S, Matsuoka K, Fujii T, Okamoto R, Yamada A, Kunisaki R, Matsuura M, Watanabe K, Shiga H, Takatsu N, Bamba S, Mikami Y, Yamamoto T, Shimoyama T, Motoya S, Torisu T, Kobayashi T, Ohmiya N, Saruta M, Matsuda K, Matsumoto T, Nakase H, Maemoto A, Yoshigoe S, Tsuchiya H, Hori-Nishi A, Hisamatsu T, iCREST-CD Study Group•
Abstract Background and Aims Fecal microbiota transplantation (FMT) from healthy donors with a normally functioning colon has limited clinical effect in the treatment of chronic pouchitis. However, a normally functioning ileal pouch–anal anastomosis (IPAA) physiology differs from individuals with a healthy intact colon. We aimed to investigate the microbial characteristics of patients with a normally functioning IPAA (HealthyPouch) compared with chronic pouchitis (SickPouch), ulcerative coliti...
Ulcerative Colitis
Dall SM, Møllekær AH, Kousgaard SJ, Jakobsen SS, Larsen L, Sørensen B, Thorlacius-Ussing O, Albertsen M•
ABSTRACT Objective To investigate the association between serum calcium levels and cold perception threshold (CPT) in patients with type 2 diabetes mellitus. Methods This retrospective study analyzed 334 type 2 diabetes mellitus patients from a tertiary hospital endocrinology department (March 2020–November 2024). Clinical, laboratory, and quantitative sensory testing (QST) data were collected. The correlations between serum calcium and cold/heat perception thresholds (CPT/HPT) were assessed...
Type 2 Diabetes Mellitus
Hao Y, Cui Q, Qin L, Sun W, Zhou S, Zhang Y, Zheng H, Ji L, Liu X, Zhang S, Cao Y, Li Y, Zhu X•
Major depressive disorder (MDD) is a leading contributor to the global burden of disease, and a substantial proportion of patients experience inadequate responses to conventional treatments. Brain-derived neurotrophic factor (BDNF), a key regulator of neuronal survival and synaptic plasticity, has been investigated as a potential biomarker of antidepressant response. However, its clinical relevance following brain stimulation remains uncertain. This systematic review evaluated changes in periphe...
Major Depressive Disorder
Galindo CD, Jemar G, Osorio IC, Lopez A, Uribe Zapata M, Gonzalez Perez L, Villamil Montejo SD, Carvajal Angarita LA•
Purpose of Review The Urology Match has become increasingly competitive over the past decade, driving rising application numbers, interview inefficiencies, and growing financial and logistical burdens for both applicants and residency programs. The Society of Academic Urology (SAU) provides governance and administrative oversight of the Urology Match and in response, has implemented several quality improvements aimed at increasing transparency, efficiency, and equity across the match process. T...
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