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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,621–1,632 of 2,098 articles

PubMed

Angiotensin-converting enzyme gene insertion/deletion polymorphism and its impact on response to azithromycin and doxycycline treatment in acne vulgaris patients.

Background: Acne vulgaris (AV) is a common inflammatory skin disorder. Systemic treatments like azithromycin and doxycycline are frequently used. The Angiotensin-Converting Enzyme (ACE) has been implicated in inflammation and skin diseases. This study investigated the association between ACE I/D polymorphism and therapeutic response to azithromycin versus doxycycline in moderate AV. Methods: This clinical trial enrolled 54 moderate AV patients divided equally into two groups: one received 100...

Articles
Tavakolizadeh A, Mohammadzadeh H, Mokhtari AM, Karami Y, Khorasani M, Saadatian Z, Rajabzadeh Z, Momeni-Moghaddam MA•
PubMed

Differential regulatory mechanisms of gut-derived SCFAs (acetate, propionate, butyrate) on the pulmonary TLR2 signaling pathway and their roles in the inflammatory balance of bacterial pneumonia.

Gut microbiota-derived short-chain fatty acids (SCFAs), key mediators in gut–lung axis interactions, profoundly influence pulmonary immune homeostasis. Toll-like receptor 2 (TLR2) is crucial for initiating innate immunity against bacterial pneumonia by recognizing bacterial molecular patterns, but its signaling requires precise regulation to balance pathogen clearance and prevent excessive inflammation-induced tissue damage. The major SCFAs—acetate, propionate, and butyrate—modulate immune respo...

Articles
Chen H, Xu Y, Qiu J, Guan Z, Yu S, Ding Y•
PubMed

Heterotopic Pregnancy After Ovulation Induction by Clomiphene Citrate: A Case Report.

Heterotopic pregnancy (HP), when intrauterine and ectopic pregnancies occur together, is uncommon but dangerous. While rare in spontaneous conception, the risk increases with fertility treatments like clomiphene citrate (CC). These cases are easily missed because doctors may be reassured by the intrauterine pregnancy and overlook the ectopic one. We describe a 31-year-old woman with primary infertility who conceived following clomiphene-induced ovulation. At seven weeks, she developed pelvic pai...

Articles
Douraidi N, Sarhane H, Belouaza FZ, Mouiman S, Baidada A•
PubMed

U-shaped and linear associations of ketogenic diet with nocturia and overactive bladder: mediation roles of frailty and platelet-to-HDL-C ratio and the influence of physical activity.

Background Ketogenic diet (KD), characterized by low carbohydrate and high fat intake, has become an increasingly popular strategy for weight management and metabolic improvement in recent years. However, its potential influence on lower urinary tract symptoms (LUTS), particularly overactive bladder (OAB) and nocturia, remains unclear. This study aimed to investigate the associations between the ketogenic diet ratio (KDR) and OAB or nocturia, and to explore the mediation roles of the frailty in...

Articles
Sun Y, Yin M, Zhou L•
PubMed

Metabolomic signaling in sarcoidosis pathogenesis.

Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating granulomas in various organs, predominantly affecting the lungs and lymphatic system. Although the etiology of sarcoidosis remains unknown, it is believed to result from an abnormal immune response triggered by environmental agents in a genetically susceptible host. The disease also has a variation in clinical outcome, with some patients spontaneously resolving their disease, while others experience disease progress...

Articles
Lotana H, White T, Drake WP•
PubMed

Hepatitis virus-associated B cell non-Hodgkin's lymphoma involves dysregulated epigenetic and RNA-mediated regulatory gene expression and altered snoRNA transcription.

Infection with HBV and its satellite virus HDV remain a significant global health issue due to their involvement in hepatic and extrahepatic diseases, including B cell non-Hodgkin’s lymphoma (BNHL). Clinical and epidemiological evidence support a causal role for HBV in BNHL development, although mechanistic insight is lacking and the role of HDV infection in this process is unknown. To help elucidate viral drivers of B cell transformation, we performed RNA-sequencing on peripheral B cells from p...

Articles
Henning AN, Budeebazar M, Boldbaatar D, Yagaanbuyant D, Duger D, Batsukh K, Muccilli S, Pardoe J, Perinet L, Conway O, Owusu-Ansah D, Robichaux K, Baumann R, Alter HJ, Dashdorj N, De Giorgi V•
PubMed

Fibronectin-Based Skin Care Regimens for Skin Recovery After Intense Pulsed Light Therapy: A Split-Face Study.

Purpose Intense pulsed light (IPL) treatment may cause transient erythema, dryness, and barrier dysfunction, highlighting the need for effective postprocedural care. This study aimed to assess the efficacy and safety of a fibronectin-containing skincare regimen in restoring skin barrier function and relieving these IPL-related manifestations. Patients and Methods In this 28-day, split-face study, 32 healthy female participants undergoing IPL treatment applied a fibronectin-containing serum to...

Articles
Feng H, Ge L, Shi G, Yu S, Wang X, Li X, Wen S, Wu L, Yi Z, Xian X, Fu X, Zhang B, Liang J, Zhu H, Ye L•
PubMed

Advancing Knowledge of Acute Cutaneous Graft-Versus-Host Disease Wound Care: A Case Study.

BACKGROUND: Acute cutaneous graft-versus-host disease (GvHD) is a frequent complication of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). It requires multidisciplinary systemic and topical management. However, no well-established recommendations regarding wound management have been established. This case study describes our experience caring for the wound of a patient with acute myeloid leukemia who developed a grade IV stage 4 acute cutaneous GvHD. CASE: Mr T...

Articles
Errichiello S, Visintini C, Rosignoli C, Cerne D, Petruzzellis G, Patriarca F, Palese A•
PubMed

Uncommon Neuro-Ophthalmologic Findings in Pediatric Lyme Disease.

Lyme disease (LD) is the most prevalent tick-borne illness in the United States and Europe, caused by a spirochete transmitted through the bite of an infected Ixodes tick. In this report, we present a case of disseminated Lyme disease in a four-year-old female who presented with constitutional symptoms and a recurrent, migratory erythema migrans-like rash for one month. The subsequent onset of eye deviation and vision complaints prompted referral, which revealed bilateral optic nerve edema and a...

Articles
Syeda UHF, Bakshi N, Sherman E•
PubMed

Gastrointestinal bleeding due to portal hypertension in cirrhosis: Prognostic value of the CAGIB score.

Abstract Introduction: Upper gastrointestinal bleeding (UGIB) due to portal hypertension (PH) is a severe complication of cirrhosis. No specific score is currently validated to assess prognosis in this setting. We aimed to evaluate the performance of the CAGIB score in predicting recurrence and early mortality following upper gastrointestinal bleedingin in cirrhotic patients. Methods: We conducted a retrospective study including cirrhotic patients hospitalized for uppergastrointestinal bleedin...

Articles
Ben Mohamed A, Mnif A, Yakoubi M, Gharbi G, Mahmoudi M, Khsiba A, Medhioub M, Hamzaoui ML•
PubMed

Sildenafil provokes headache but not migraine in men with migraine without aura: a randomized, placebo-controlled crossover trial.

Background Cyclic guanosine monophosphate (cGMP)-mediated mechanisms plays a role in migraine pathophysiology. Sildenafil, a phosphodiesterase type 5 inhibitor, increases intracellular cGMP and can reliably induce migraine attacks in women. However, its migraine-inducing potential in men remains largely unknown. Methods In this randomized, double-blind, placebo-controlled crossover trial, 12 men with migraine without aura received sildenafil (100 mg) and placebo in separate sessions ≥ 7 days...

Articles
Mohammad A, Iversen DB, Rausgaard NLK, Kruuse C, Beier D, Stage TB, Pellesi L•
PLOS

Community management: An effective model to reduce medication discontinuation rate in patients with schizophrenia

Background: Medication discontinuation is highly prevalent among patients with schizophrenia and is associated with poor clinical outcomes. Although community-based management models have been implemented in China to support patients, recent evidence of their effectiveness in reducing medication discontinuation rates remains limited. Methods: In this cross-sectional study, we surveyed 1,531 patients with schizophrenia under community management in Chengdu, China, using a multi-stage sampling app...

Articles
Hua Ren, Qin Yang, Changjiu He, Jian Jiao, Zaiquan Dong•