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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,681–1,692 of 2,098 articles

PubMed

Methylprednisolone plus MTX-based regime vs prednisone-based standard of care for GCA: a propensity score study.

Abstract Objectives Treatment of GCA still requires substantial exposure to glucocorticoids (GCs), which are associated with significant toxicity. This study compares the efficacy and safety of the GC-only standard of care (SOC) with a regimen combining intravenous methylprednisolone (IVMP) pulses, MTX and lower doses of prednisone, in newly diagnosed patients with GCA. Methods A usual clinical practice study was conducted in three Spanish academic hospitals. One hundred and fifty-one patien...

Articles
Soto-Peleteiro A, Hernández-Rodríguez J, Raad F, de Miguel B, Acha L, Torio M, Hernandez-Negrin H, Gómez-Caverzaschi V, Ruiz-Arruza I, Araujo O, Prieto-González S, Espígol-Frigolé G, Cid MC, Ruiz-Irastorza G•
PubMed

Pharmacist-Led Intervention to Enhance Direct Oral Anticoagulant Adherence and Treatment Outcomes in Atrial Fibrillation: A Pragmatic Clinical Trial.

Purpose This study aims to evaluate the impact of a pharmacist-led education program on medication adherence and treatment outcomes among patient with atrial fibrillation (AF) using direct oral anticoagulants (DOACs) for stroke prevention. Additionally, we will compare self-reported adherence with claims data and examine whether DOAC blood concentration can serve as a biomarker for medication adherence and treatment outcomes. Patients and Methods We will conduct a pragmatic randomized control...

Articles
Liu SY, Huang YM, Lin SY, Wang CC•
PubMed

Evaluation of Arabica coffee pulp extract on sperm quality and hematology in cyclophosphamide-treated rats.

Cyclophosphamide (CYP) is a widely used chemotherapeutic agent. Its administration is associated with detrimental effects on sperm quality and hematological indices. Coffee pulp Arabica (Coffea arabica L) is a coffee by-product with considerable antioxidant potential. This research investigated the effects of Arabica coffee pulp extract (CPE) against CYP on sperm quality and hematological indices. A total of 20 rats were used with five treatment groups: Control: plain water; CYP: 150 mg/kgbw CYP...

Articles
Maulana SA, Widiyanto S, Khoerul M, Munasir•
PubMed

Weekly Subcutaneous VK2735, a GIP/GLP-1 Receptor Dual Agonist, for Weight Management: Phase 2, Randomized, 13-Week VENTURE Study.

ABSTRACT Objective This study aimed to determine doses of VK2735, a novel glucagon‐like peptide‐1/glucose‐dependent insulinotropic polypeptide (GLP‐1/GIP) receptor dual agonist, that are effective for weight loss over 13 weeks of treatment. Methods VENTURE was a phase 2, randomized, double‐blind, placebo‐controlled, dose‐ranging study of weekly subcutaneous VK2735 in adults with obesity or overweight and ≥ 1 weight‐related comorbidity. Participants with diabetes mellitus were ineligible. The...

Articles
Bays HE, Toth P, Alkhouri N, Pullman J, Freilich B, Neutel J, Ji S, Stubbe S, Hedges P, Lian B•
PubMed

Deprivation indices and their association with fragility fractures and bone density: evidence from a large observational cohort.

Abstract Objectives Socioeconomic deprivation as a fracture risk factor remains underexplored. We evaluated associations between deprivation indices and bone health outcomes in a UK clinical population. Methods A total of 40 951 patients aged ≥50 years underwent DXA scanning between June 2004 and May 2025 in northwest England. Socioeconomic status was assessed using the Index of Multiple Deprivation (IMD) and Townsend Deprivation Score (TDS). Generalised additive models examined associations...

Articles
Amin H, Khan MA, Bukhari M•
PubMed

Investigating the association between urban rural classification with fragility fractures and bone density in the UK: evidence from a large observational clinical cohort.

Abstract Objectives Geographic variation in fracture risk exists across the UK, yet rural/urban differences in fracture risk and bone density have yet to be explored. We aimed to investigate associations between rural urban classification (RUC) and bone health outcomes in a UK clinical population. Methods We analysed patients who underwent DXA scanning between June 2004 and May 2025 in northwest England. Geographic status was assessed using the 2011 UK Census RUC. Multiple imputation with pa...

Articles
Amin H, Khan MA, Bukhari M•
PubMed

Effect of high dietary lysine on growth performance and body composition in weaned pigs following a period with dietary protein restriction: a preliminary study.

Abstract Increasing dietary Lys and remaining essential amino acids (AA) above requirements might counter impaired growth resulting from pigs being fed a low-protein (LP) diet in the early weaning period. It was hypothesized that by increasing dietary Lys and remaining essential AA levels in a 4-week (W) non-reduced period (W5–8) after a 4-W reduced dietary crude protein period (W1–4) would potentially increase growth performance. At weaning, 67 piglets with an ADG of 200–220 g/day during the s...

Articles
Ruggeri R, Girard M, Silacci P, Bee G, Larsen C, Madsen JG•
PubMed

Saudi Clinical Practice Guideline for the Assessment and Management of Low Back Pain and Sciatica in Adults.

Background/Objectives: Low back pain (LBP) is the leading cause of disability in Saudi Arabia and contributes substantially to healthcare utilisation, reduced quality of life, and lost productivity. This guideline provides nationally standardised, evidence-based recommendations for the assessment and management of non-specific LBP and sciatica in adults, adapted to the clinical and health-system context in Saudi Arabia. Methods: A multidisciplinary Task Force developed the guideline using the GR...

Articles
Aldera M, Alturkistany A, Al Rayes H, Rada G, Alsulaimany HH, Alsobayel HI, Alghamdi K, Awwad W, Alyamani OA, Bedaiwi M, Alqahtani Y, Almaghlouth I, Bahlas SM, Alazmi MS, Brunnhuber K, Alhelal F, Alshehri MA•
PubMed

Is "Open Stone Surgery with Intraoperative Nephroscopy" a Better Alternative to Percutaneous Stone Removal for Complex Kidney Stones in Resource-Constrained Rural Settings?: A Retrospective Observational Cohort Study.

Introduction and Importance Advances in endourology have greatly reduced open stone surgeries (OSS) worldwide. However, in some rural areas of developing countries, PNL for large, complex stones is not feasible due to limited resources and lack of angioembolisation. We share our experience in such cases. Materials and Methods Using STROCSS 2025 and PROCESS 2023 checklists, we outlined objectives and reported a case series. From January 2012 to June 2023, 2241 patients had surgery for urinary...

Articles
Chakraborty JN, Kikon R•
PubMed

Prevalence and determinants of intestinal parasitic infections among children under five years attending Bule Hora University Teaching Hospital, Southern Ethiopia.

Background Intestinal parasitic infections (IPIs) remain a significant public health issue, especially among young children in developing countries, and they contribute to illness and death. Factors such as poor hygiene, inadequate sanitation, and limited access to clean water worsen the spread of these infections. This study aims to determine the prevalence of intestinal parasites (IPs) and identify related risk factors among children under five years old at Bule Hora University Teaching Hospi...

Articles
Gena ME, Seyoum S, Angelo AA•
PubMed

Readability and quality assessment of AI-powered chatbot responses to overactive bladder patient questions: a comparative study.

Introduction Overactive bladder (OAB) is a common urological condition affecting millions of people worldwide, significantly reducing their quality of life. Patient compliance and active participation in disease management are critical to achieving successful outcomes. This study aims to understand the potential role of AI-assisted chatbots in educating patients with OAB and their impact on health literacy. Methods We compared responses from four AI chatbots (ChatGPT, DeepSeek, Claude, and Ge...

Articles
Deger M, Ates T, Yilmaz IO, Arıkan MG, Sukur IH, Ok F, Akdogan N, Izol V•
PubMed

A Comprehensive Assessment of Health-Related Quality of Life in Hereditary Angioedema as a Patient-Centered Approach.

Abstract Introduction Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH) has a substantial impact on patients’ health-related quality of life (HRQoL). While generic instruments are frequently used for assessment, they may not fully capture the disease-specific burden. This study aimed to evaluate HRQoL in patients with HAE-C1INH types I and II using validated, angioedema-specific tools. The aims of the study were to assess HRQoL and disease control in patients with HAE-C1INH usin...

Articles
Yalcin Gungoren E, Karabiber E, Yorgun Altunbas M, Can S, Tusuz Onata E, Atik O, Dikici U, Meric Z, Ozanli I, Amirov R, Ozturk N, Bozkurt S, Eser Simsek I, Kiykim A, Ozek Yucel E, Bogatekin G, Aydogan M, Tepetam FM, Ozdemir O, Yilmaz EA, Mete Gokmen EN, Bilgic-Eltan S, Baris S, Ozen A, Karakoc-Aydiner E•