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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,717–1,728 of 2,098 articles

PubMed

Smartphone-Based Digital Eczema Education Program for Atopic Dermatitis in Children Aged 0 to 6 Years: Multicenter, Randomized, Parallel Controlled Clinical Study.

Abstract Background Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition that affects approximately 10% to 20% of children, imposing substantial health and economic burdens. Although education for patients and caregivers is acknowledged as a crucial element in the management of AD, conventional approaches, such as workshops or in-person consultations, are often resource intensive and face challenges related to scalability, personalization, and relapse prevention. Digital...

Articles
Yang H, Shu H, Wang LH, Li P, Li YL, Li QF, Han XP, Tian J, Chang J, Qian H, Chen JP, Ding XQ, Wu PQ, Dou LM, Luo Z, Li W, Lin YY, Li L, Yue SZ, Gu Y, Yang L, Sun XH, Luo XY, Ma L, Wang H•
PubMed

Holmium laser enucleation of the prostate versus transurethral resection of the prostate for benign prostatic hyperplasia: evidence from a Korean retrospective analysis using the Common Data Model.

Background The aim of this study was to evaluate and compare the efficacy and safety of transurethral resection of the prostate (TURP) and holmium laser enucleation of the prostate (HoLEP) for treating benign prostatic hyperplasia using standardized multicenter data. Materials and methods We retrospectively collected data from six Korean hospitals using the Common Data Model and performed a meta-analysis. Patients were categorized into TURP (control) and HoLEP (experimental) groups, and risk...

Articles
Lee Y, Lim C, Kim K, Park S, Cho D, Kim WB, Kang BJ, Choi SY•
PLOS

Rapid, label-free surface plasmon resonance discrimination between Bothrops and Crotalus venoms using clinical antivenom as the capture reagent

Snake envenoming is recognized as a global health problem, affecting thousands of people every year. One of the main challenges in addressing this issue is the correct identification and treatment of these envenomations, particularly in locations where people do not have easy access to hospitals. In Brazil, the genus Bothrops is responsible for the majority of envenomations, followed by Crotalus. This study reports a simple methodology for detecting crude venom from snakes of the genus Bothrops,...

Articles
Ely S. F. Borges, Jomar S. Vasconcelos, Arthur A. Melo, Fernanda C. C. L. Loureiro, Karla P. O. Luna, Antonio M. N. Lima•
PLOS

Validity of the International Fitness Scale (IFIS) and its associations with cardiometabolic health and body composition in adults with type 2 diabetes: A cross-sectional study

Aims: To assess the validity of the International Fitness Scale (IFIS) for evaluating cardiorespiratory fitness compared to the 6-minute walk test (6MWT) (criterion validity) and to examine associations with cardiometabolic and body composition outcomes (construct validity). Methods: A cross-sectional analysis was conducted on 282 adults with type 2 diabetes mellitus (T2DM) (mean age 63.6 ± 8.1 years, 37.9% women). Self-reported fitness was assessed using IFIS, including overall, cardiorespirato...

Articles
Ángel Herraiz-Adillo, Karin Rådholm, Fredrik Iredahl, Carl-Johan Carlhäll, Nahuel Roemkens, Mikael Forsgren, Olof Dahlqvist Leinhard, Peter Lundberg, Stergios Kechagias, Nils Dahlström, Patrik Nasr, Mattias Ekstedt, Pontus Henriksson•
PLOS

Impact of improved stove intervention on infant acute respiratory infections: Results from a randomized trial in Northwest Ethiopia

Background: Globally, millions of young children affected by acute respiratory infections every year, which is the leading cause of death and serious illness among children. Though strategies, including promoting improved stoves, have been implemented to combat this public health challenge, the effectiveness of local improved stoves introduced during pregnancy in reducing household air pollution and related respiratory illnesses remains limited. Method: Following the main trial randomization, 34...

Articles
Habtamu Demelash Enyew, Abebe Beyene Hailu, Seid Tiku Mereta•
PLOS

Association between body image satisfaction and depressive symptoms among young women in the UAE with Polycystic Ovary Syndrome (PCOS) and Non-PCOS: A comparative quantitative cross-sectional study

Background: Polycystic Ovary Syndrome (PCOS) is one of the most common conditions affecting women of reproductive age, significantly impacting both physical and psychological well-being, often leading to depressive symptoms and lower body image satisfaction. The prevalence of Polycystic Ovary Syndrome among women in the United Arab Emirates (UAE) is increasing. However, the psychological effects of Polycystic Ovary Syndrome on women in the UAE remain underexplored due to cultural sensitivities s...

Articles
Shaima Abdrahman AlMekhlafi, Maria Susana Campo-Redondo•
PLOS

Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment

MED12 exon 2 mutation is the most frequent mutation associated with uterine leiomyomas. MED12 wild-type leiomyomas have a higher growth potential than mutant leiomyomas, suggesting that the mutation limits leiomyoma growth. MED12 forms a complex with CDK8 and is involved in the phosphorylation of RNA polymerase II, playing a role in transcriptional regulation. However, its mechanism of action in leiomyoma growth is not clear. We aimed to clarify the relationship between MED12 mutation status, re...

Articles
Saki Tanioka, Ryoko Asano, Yukihide Ota, Koichi Nagai, Katsuya Takenaka, Taichi Mizushima, Yohei Miyagi, Etsuko Miyagi•
PLOS

The association between rural/urban residence status and patient-reported outcomes in individuals with Chronic Obstructive Pulmonary Disease (COPD): Protocol for a systematic review and meta-analysis

Introduction: Rural residency is associated with a disproportionate burden of chronic obstructive pulmonary disease (COPD) and poorer COPD health outcomes. While increasing focus has been placed on the influence of rural/urban residence on clinical outcomes, little is known about the impact of rural versus urban residency status on patient-reported outcome measures (PROMs) in individuals with COPD, despite the use of PROMs to tailor interventions and treatments to individual patient needs. Objec...

Articles
McKenzie Granata Green, Laurie L. Meschke, Thankam Sunil, Javiette Samuel, Kristina W. Kintziger, Phoebe M. Tran•
PLOS

Barriers and facilitators to antibiotic stewardship in Nigeria’s private healthcare sector: A qualitative interview study with national health and regulatory interest holders

Antimicrobial resistance (AMR) poses a growing global health concern, particularly in low- and middle-income countries (LMICs) such as Nigeria, where stewardship efforts have largely overlooked the private healthcare sector. Given that most Nigerians seek care from private providers, understanding the barriers and opportunities for implementing antibiotic stewardship programs in this setting is critical. We conducted a qualitative study consisting of semi-structured interviews with 14 interest h...

Articles
Aaya Mahdi, Sarah Pascale Ngassa Detchaptche, Joel Shyam Klinton, Nnakelu Eriobu, Blessing Uche, Nawal Maredia, Charity Oga-Omenka, Giorgia Sulis•
PubMed

Caffeic acid phenethyl ester alleviates 1,2-dichloroethane-induced toxic cerebral edema: central and peripheral mechanisms.

Background 1,2-Dichloroethane (1,2-DCE) is a widespread environmental contaminant as well as a frequent occupational hazard. Given that inflammation and oxidative stress are key mechanisms in 1,2-DCE-induced cerebral edema, we investigated the efficacy of caffeic acid phenethyl ester (CAPE), a natural anti-inflammatory and antioxidant agent known to protect blood-brain barrier (BBB) integrity, against this intoxication and explored its underlying mechanisms. Methods Static inhalation exposure...

Articles
Sun Y, Yin B, He S, Miao L, Yang J, Wang Y, Jin X•
PubMed

Emergency Roux-en-Y Biliary Bypass and Duodenal Exclusion for Perforated Duodenal Ulcer.

Perforated duodenal ulcers are a life-threatening surgical emergency with high morbidity and mortality; however, there is a paucity of literature describing the operative management of perforated ulcers involving the common bile duct (CBD). This manuscript describes the case of a woman in her 60s with multiple comorbidities who underwent emergency abdominal surgery for a large perforated duodenal ulcer with extension into the CBD. An intraoperative decision was made to perform a Roux-en-Y biliar...

Articles
Zalums AZ, Hook H•
PubMed

Nuts about pemphigus? A cross-sectional investigation into the role of nuts intake in modulating disease severity.

Abstract Background Given the anti-inflammatory properties of nuts, their consumption might play a role in reducing inflammation and the severity of pemphigus vulgaris (PV). However, limited evidence exists regarding the association between nut intake and PV severity. Thus, this cross-sectional study investigates the relationship between PV severity and the consumption of total nuts as well as specific nut varieties. Methods This study included 138 PV patients, of whom 108 had a Pemphigus Di...

Articles
Fallah M, Fahimzad FS, Najafi A, Zeinalabedini M, Balighi K, Daneshpazhooh M, Ebrahimpour-Koujan S•