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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,873–1,884 of 2,098 articles

PubMed

Topical Trichosanthis Radix Water Extract Attenuates Atopic Dermatitis-Like Skin Inflammation: Marker Standardization, Network Pharmacology, and Preclinical Validation.

Trichosanthis Radix (TR) is a pharmacopeial crude drug traditionally used to clear heat, reduce swelling, expel pus, and generate fluids, suggesting potential relevance to inflammatory skin disorders such as atopic dermatitis (AD). In this study, we evaluated the AD‐related activity of a TR water extract using an integrated workflow combining network‐based target analysis, marker compound analysis, and experimental validation in vivo and in vitro. The overlap between predicted TR targets and AD‐...

Articles
Kim HM, Kim GL, Gil TY, Sim HY, Lee H, Lee DS, Lee KY, An HJ•
PubMed

Population-Level Burden of Dermatitis and the Effects of Moxibustion and Capsaicin on Pruritus and JAK/STAT Signaling in Atopic Dermatitis: A Multilevel Study.

Purpose This study comprised two complementary levels of investigation. First, we characterized the global burden, temporal trends, and socioeconomic inequalities of dermatitis as an aggregated disease category. Second, within this broader public‐health context, we investigated whether moxibustion and topical capsaicin alleviate pruritus and inflammatory skin damage in a rat model of atopic dermatitis (AD) and explored their potential convergent regulation of the Janus kinase (JAK)/STAT signali...

Articles
Yang Y, Guo L, Yang Y, Tang H, Kuang H, Lin L, Gou Y, Li S, Zhao H•
PubMed

Mechanistic Study of Yibi Decoction in Treating Rheumatoid Arthritis via Modulating the JAK2/STAT3 Signaling Pathway.

Introduction/Objective To investigate the therapeutic effects of Yibi Decoction (YBD) in rheumatoid arthritis (RA) and to elucidate the underlying mechanisms, with a particular focus on the JAK/STAT signaling pathway. Methods Network pharmacology analysis was employed to predict the bioactive compounds and potential therapeutic targets of Yibi Decoction. A collagen-induced arthritis (CIA) rat model was established to validate the predicted effects in vivo. Western blotting, enzyme-linked immu...

Articles
Huang C, Chen S, Chen Y, Xia T•
PubMed

Therapeutic Potential of Phellodendrine/ Atractylenolide-I Combination in Rheumatoid Arthritis: Targeting Neutrophil Apoptosis through LTB4/BLT1 Pathway Suppression.

Introduction To investigate the therapeutic effects of rheumatoid arthritis (RA) Phellodendrine and Atractylenolide-I (PHE/ATL-1) on RA and their mechanisms. Methods In this study, first clinical experiments were conducted to investigate whether the delayed neutrophil apoptosis in the course of RA was related to the Leukotriene B4 (LTB4)/ Leukotriene B4 receptor 1 (BLT1) pathway, and then the effects of PHE/ATL-1 inhibition of the LTB4/BLT1 pathway to promote neutrophil apoptosis to inhibit i...

Articles
Qin Z, Tang R, Jiang G, Yin J, Xu S, Wang Q, Cai K, Liang J, Zhang M, Jia X•
PubMed

Revealing Metabolic Reprogramming Genes as Biomarkers of Rheumatoid Arthritis: A Bioinformatics Study Based on Ensemble Learning Approach and Single Cell RNA Sequencing.

Introduction Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Emerging evidence suggests that metabolic reprogramming plays a pivotal role in rheumatoid Arthritis (RA) pathogenesis. However, existing studies have focused predominantly on isolated pathways. This study aimed to systematically investigate the molecular interplay between metabolic reprogramming and immune dysregulation in RA. Methods Twe...

Articles
Cheng L, Zong H, Li D, Qian L•
PubMed

Randomized comparison of continuous versus intermittent bolus furosemide in neonatal heart failure.

Background and Aims: In term neonates with heart failure, optimizing diuresis is critical, yet evidence for best practice is sparse. This study aims to compare the effectiveness of continuous infusion versus intermittent bolus furosemide in improving pulmonary status, hemodynamics, renal function, and intensive care unit (ICU) length of stay in neonates with heart failure. Materials and Methods: A randomized trial was conducted involving 52 infants (26 per group) to compare continuous infusio...

Articles
Ahmadipour M, Razi L, Jamali Z, Allahdini I, Ahmadi HF•
PubMed

L-Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies.

ABSTRACT Introduction Insomnia and other sleep disorders are becoming increasingly prevalent worldwide, while current sedative medications such as benzodiazepines, though effective, are often limited by side effects and dependency risks. Therefore, identifying safe natural compounds with sedative potential is of growing scientific and clinical interest. L‐quebrachitol (LQL), a naturally occurring cyclitol compound with antioxidant, antimicrobial, and antidiabetic properties, has not been previ...

Articles
Asrafi A, Aslam M, Al Hasan MS, Uddin MB, Mia E, Alshahrani MY, Bithi SA, Akter MS, Hossain MA, Islam MT•
PubMed

Effects of Diazepam on Oxidative Stress, Apoptosis, and Vascular Reactivity in Human Umbilical Arteries Under Experimental Hyperhomocysteinemia.

In obstetrics, diazepam is commonly used to treat anxiety, insomnia and as a second‐line treatment for seizures in preeclampsia and eclampsia. However, the effects of diazepam on the oxidative balance and vascular function of the umbilical circulation are still insufficiently studied. In this study, we investigated the effects of suprapharmacological concentrations of diazepam in an in vitro model of human umbilical artery (HUA) injury, induced by incubation with 1 mM homocysteine, representing...

Articles
Gajić Bojić M, Ritan Mičić Z, Stojmenovski A, Bojanić A, Jovičić S, Matičić M, Mandić-Kovačević N, Uletilović S, Amidžić L, Savić M, Škrbić R•
PubMed

Systematic Review and Meta-Analysis: Association Between Circulating and Tissue Levels of Selenium and Zinc and Breast Cancer Risk.

Background Selenium (Se) and zinc (Zn) are essential micronutrients that play roles in antioxidant defense and the regulation of cell proliferation. Increasing evidence suggests that disturbances in trace element balance may contribute to breast carcinogenesis; however, findings across studies remain inconsistent. Objective To evaluate the association between circulating and tissue Se and Zn levels and breast cancer. Methods A systematic review and meta‐analysis were conducted according to...

Articles
Lucarelli AP, Martins MM, Teruya MM, Yauti TT, Hayashi DR•
PubMed

Generation of selenium nano- and micro-materials using abiotic and biotic processes.

We have previously described the generation of Metal Organic Biohybrids (MOBs) as self-assembling structures that are formed by a combination of a biological component (amino acid), and a metal, such as copper. This MOBs synthesis process has now been distilled to be purely biochemical (a green chemistry process), or abiotic, not requiring the presence of cells. Building on these discoveries, in this commentary we describe the use of selenium for the first time using MOBs synthesis techniques, a...

Articles
Wells M, Rugg K, Urmee H, Etheridge J, Boudreaux C, Fairley N, DeCoster MA•
PubMed

Neuroprotective effect of selenium in rats subjected to chronic intermittent cold and immobilization stress: The role of phosphorylated tau.

Objective(s): The current study aimed to investigate the potential neuroprotective effect of selenium against cognitive dysfunction in rats subjected to chronic intermittent stress. Materials and Methods: Ninety adult male Wistar rats were randomly assigned into five groups (n=18): (1) N: non-stressed group; (2) CS: cold-stressed non-treated group; (3) IS: immobilized-stressed non-treated group; (4) CS/Se: cold-stressed/ selenium-treated group; and (5) IS/Se: immobilized-stressed/selenium-tre...

Articles
Abdallah MA, Abdel-Razek HAD, Saleh SA, Elseadawy RSA, Kora MA, Younis AG, Salem HR•
PubMed

The Impact of Selenium Deficiency and Supplementation on Hashimoto's Thyroiditis: A Clinical Evaluation.

Introduction Hashimoto thyroiditis (HT) is an autoimmune disorder that leads to hypothyroidism. Selenium (Se) is essential for thyroid hormone metabolism and immune function, but its role in HT remains debated. This study investigates Se levels in HT patients and evaluates the impact of supplementation on thyroid autoimmunity and thyroid function. Methods This retrospective study analyzed HT patients and healthy controls. Biochemical parameters, including Se, thyroid-stimulating hormone (TSH)...

Articles
Acik H, Aydin Y•