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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 2,005–2,016 of 2,098 articles

PubMed

HuangE Capsules Improve Bladder Function in BOO-induced Overactive Bladder Rats: Network Pharmacology and Experimental Validation.

Aims Our objective is to assess the therapeutic impact of HEC on OAB rats and investigate potential mechanisms. Background Overactive bladder (OAB) is a syndrome of urinary storage symptoms characterized by “urinary urgency with or without urinary acute incontinence, usually accompanied by increased daytime and nocturnal urination”, which impacts patients’ quality of life. We found the potential therapeutic impact of HuangE capsules (HEC) on OAB patients through clinical practice. However, th...

Articles
Li P, Pang Y, Zhao S, Liu H, Han S, Zhong R, He S, Shi J, Cheng H, Gong H, Yan Y, Duan J•
PubMed

The association of parental use of new tobacco products and combustible cigarettes with nausea and vomiting in pregnancy: a cross-sectional study.

Background New tobacco products, including heated tobacco products and electronic cigarettes, are rapidly increasing in popularity among younger populations worldwide, particularly in Japan. Thus, clarifying the effects of both active and passive smoking of new tobacco products during pregnancy is an urgent public health concern. We focused on nausea and vomiting in pregnancy (NVP) which is traditionally and epidemiologically considered an indicator of healthy pregnancy progression. In this stu...

Articles
Akiyama M, Michikawa T, Takeda Y, Nagasaki S, Sakuma J, Asakura K, Nakata M, Nishiwaki Y•
PubMed

Nalmefene Mitigates Opioid-Induced Nausea and Vomiting in Postoperative Analgesia but Not Resting Pain.

Background Patient‐controlled analgesia (PCA) pumps have emerged as the prevalent modality for managing postoperative pain. Opioids, although widely utilized as analgesic agents in these pumps, are often accompanied by undesirable side effects that can compromise patient comfort and hinder the widespread adoption of PCA therapy. Methods We conducted a retrospective study involving 392 patients undergoing lumbar spine surgery who were prescribed PCA pumps for pain relief. Over the initial 1–3...

Articles
Yang J, Zhang B, Qiu L, Zeng Q, Xie J, Sun J•
PubMed

Enhancing the Visibility of Multiple Sclerosis Lesions using Fused Images of Fluid Attenuated Inversion Recovery (FLAIR) and white matter Attenuated Inversion Recovery (WAIR) MRI Sequences.

Introduction Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system in which accurate lesion detection is essential for diagnosis and follow-up. Although the Fluid Attenuated Inversion Recovery (FLAIR) MRI sequence is routinely used, it may underestimate lesions in certain brain regions. This study evaluated whether fused images generated using minimum pixel value extraction (MinPE) from FLAIR and white matter–attenuated inversion recovery (WAIR) sequences improve...

Articles
Alanazi K, Abujamea A, Amjad MF, Fahad A, Abdu A•
PubMed

Associating a Polygenic Risk Score for Multiple Sclerosis with Brain MRI Metrics and Cognitive Performance in Healthy UK Biobank Participants.

Purpose Multiple sclerosis (MS) is a demyelinating disease of the central nervous system influenced by both genetic and environmental factors. Although a polygenic risk score for MS (MS-PRS) is associated with disease susceptibility, its relationship with white matter (WM) microstructure and cognition in neurologically healthy individuals remains unclear. This study investigated associations of MS-PRS with diffusion MRI metrics and cognitive function in healthy individuals. Methods This cross...

Articles
Feng C, Kikuta J, Hagiwara A, Zou R, Ma S, Guo S, Kitagawa T, Mizuta K, Takabayashi K, Wada A, Takai I, Hoshino Y, Tomizawa Y, Hatano T, Kamagata K•
PubMed

Phase Image Display Settings for Paramagnetic Rim Lesion Detection in Multiple Sclerosis: A Practical Guide.

The 2024 revisions of the McDonald criteria incorporate the paramagnetic rim lesion (PRL) into the diagnostic framework of multiple sclerosis, and PRL evolution is increasingly recognized as a marker of disease progression. PRLs are detected on phase images of susceptibility-sensitive sequences, but their visibility depends critically on display settings. Current consensus recommendations provide detailed guidance on acquisition parameters yet do not address the phase-image window/level applied...

Articles
Hagiwara A, Sonoda Y, Tomizawa Y, Shinoda K, Takai I, Hoshino Y, Kikuta J, Hatano T, Kamagata K•
PubMed

Headache Frequency and Depressive Symptoms Are Independently Associated With Disability in Migraine: A Large-Scale, Cross-Sectional Study.

Objective The burden of migraine is influenced by a complex interplay of headache characteristics, psychiatric comorbidities, and sleep disturbances. This study aimed to examine factors independently associated with migraine‐related disability and severe functional impairment in a large clinical cohort. Methods This cross‐sectional study included 1186 patients diagnosed with migraine according to ICHD‐3 criteria. We collected data on demographics, headache characteristics (monthly headache da...

Articles
Pu Y, Deng D, Yao Y, Hong F, Zheng Y, Mao M•
PubMed

Letter to the Editor regarding: "Lipid-lowering therapy in patients with hypercholesterolemia in terms of the POLSCORE and SCORE2 scales. A single-center retrospective analysis".

I read with great interest the study by Rogozik et al. [1], which demonstrated that cardiovascular risk assessed using SCORE2 was substantially higher than that estimated with Pol-SCORE in patients with hypercholesterolemia without established cardiovascular disease. Through risk reclassification and comparisons of treatment status between the two scoring systems, the authors further showed that many individuals classified as high or very high risk by SCORE2 were discharged without lipid-lowerin...

Articles
Kimura R•
PubMed

Unraveling the Pathogenetic Potential and Immune Crosstalk of Yersinia spp. in Inflammatory Bowel Disease.

Yersinia enterocolitica and Yersinia pseudotuberculosis have been identified as microbiological factors in the multifactorial pathophysiology of inflammatory bowel disease (IBD). Although conventionally associated with self‐limiting gastroenteritis, Yersinia has been increasingly investigated for its potential role in IBD, particularly in genetically predisposed individuals. Whether this reflects causality, opportunistic colonization, or secondary enrichment within inflamed tissue, however, rema...

Articles
Sabzehali F, Zerbato V, Bella SD, Morabito S, Zali MR, Yadegar A•
PubMed

Association Between Inflammatory Bowel Disease and Venous Leg Ulcers: Insight From Mendelian Randomization Analyses.

Background This study aimed to investigate the potential causal relationship between inflammatory bowel disease (IBD) and venous leg ulcers (VLU) using Mendelian randomization (MR). Materials and Methods Independent genetic variants for IBD and VLU were selected as instruments from previously published genome‐wide association studies (GWAS) in people of primarily European descent. MR analyses were carried out utilizing inverse‐variance weighted (IVW), weighted median, MR Egger, simple mode, a...

Articles
Lin Y, Qin X, Zhang H, Huang J•
PubMed

Optimising Blood Test Monitoring Frequency for Inflammatory Bowel Disease Patients: Balancing Adherence, Comfort and Risk.

Background Inflammatory bowel disease (IBD) therapies can cause myelosuppression and hepatitis. The European Crohn’s and Colitis Organisation (ECCO) recommends 3‐monthly blood test monitoring; however, these recommendations are largely based on expert consensus, and real‐world evidence informing optimal long‐term monitoring intervals remains limited. Aim To determine the incidence of medication‐related hepatitis and myelosuppression in a population‐based IBD cohort and estimate the laboratory...

Articles
Ravikulan A, Irwin J•
PubMed

Exploring the Comorbidity Mechanism among Functional Diarrhea, Irritable Bowel Syndrome with Predominant Diarrhea, and Functional Dyspepsia through the Gut-brain Axis and the Pharmacological Mechanisms of Shen-Ling-Bai-Zhu-San Therapy.

Background Functional Diarrhea (FDr), Irritable Bowel Syndrome with predominant diarrhea (IBS-D), and Functional Dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) with significant impacts on quality of life. While the gut-brain axis and key regulators like 5-hydroxytryptamine (5-HT), dopamine (DA), and butyrate are known to play crucial roles in these conditions, the mechanisms underlying their comorbidities remain unclear. Shen-Ling-Bai-Zhu-San (SLBZS), a traditional herb...

Articles
Mei CF, Han LL, Xue H•