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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 205–216 of 2,098 articles

PubMed

Case Report: Uncommon MRI and PET/CT Imaging Findings in a Rare Case of Vertebral Sarcoidosis.

Sarcoidosis is a systemic inflammatory granulomatous disease that can affect almost any body organ. Among the musculoskeletal manifestations, which are uncommon, vertebral sarcoidosis is extremely rare, while depicting a significant variability in radiological features. We present a unique case of a 52‐year‐old male, who was referred for MRI of the lumbar spine due to inflammatory back pain. Disc bulging at the intervertebral spaces L1/L2, L4/L5, and L5/S1 was found, without any signs of spinal...

Articles
Hammadi WHH, Varvounis M, Foufa K•
PubMed

Mitral valve disease in rheumatic heart disease, systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid Arthritis.

Mitral valve disease occurs in rheumatic heart disease (RHD) and selected systemic autoimmune rheumatic diseases, but similar lesions may have different underlying mechanisms. This structured narrative review examines epidemiological, mechanistic, imaging, and management evidence, distinguishing established pathways from incompletely validated mechanisms and hypotheses. In RHD, post-streptococcal valvulitis leads to fibrotic remodeling, commissural fusion, and chordal shortening, producing mitra...

Articles
Lucki M, Grygiel-Górniak B, Lucka E, Lesiak M•
PubMed

Atraumatic Interspinous Bursitis in an Adolescent-A Case Report.

ABSTRACT Cervical interspinous bursitis is an important cause of cervical spine pain, with the diagnosis relying on both clinical findings and higher order imaging in the form of MRI. We present a rare case of exercise‐associated cervical interspinous bursitis in a pediatric patient.

Articles
McKenna DP, Davey MS, O'Toole P, Alberghina F•
PubMed

Crohn's Disease Requiring Different Surgical Interventions in Presumed Monozygotic Twin Brothers: A Case Report.

ABSTRACT INTRODUCTION Crohn’s disease (CD) in both members of a presumed monozygotic twin pair is uncommon. We report twin brothers who developed ileocolonic and perianal CD 2 years apart but required different surgical interventions. This report highlights the value of prompt evaluation of a symptomatic cotwin and individualized surgical decision-making. CASE PRESENTATION Twin 1 developed a perianal abscess at the age of 16 years, followed by severe rectosigmoid inflammation and fixed steno...

Articles
Matsunaga K, Matsuda K, Kotani T, Abe K, Kondo R, Omichi K, Nishikawa T, Masuda W•
PubMed

Beyond the gut: Non-specific interstitial pneumonia in pediatric ulcerative colitis-A rare extra-intestinal manifestation.

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder often presenting with extra‐intestinal manifestations (EIMs) involving the skin, joints and eyes. However, pulmonary manifestation, such as interstitial lung disease (ILD), is a rare complication, particularly in the pediatric population. We report a case of a 10‐year‐old boy, with very early onset IBD‐ulcerative colitis, presented with non‐productive cough, fever and dyspnea, with examination findings revealing respir...

Articles
Vachher H, Poojari V, Tetarbe S, Chandane P, Shobhavat L, Shah I•
PubMed

Licoflavone B mitigates allergic rhinitis by restraining epithelial PI3K-AKT/NF-κB NLRP3 inflammasome signaling.

Allergic rhinitis remains highly prevalent and is often incompletely controlled by current therapies, while accumulating evidence implicates epithelial PI3K–AKT/NF-κB-mediated activation of the NLRP3 inflammasome in upper-airway inflammation. This study investigated whether the licorice-derived flavonoid Licoflavone B (LFB) alleviates allergic rhinitis by modulating this signaling axis. In an ovalbumin-induced murine model, allergic rhinitis-like symptoms and nasal histopathological changes were...

Articles
Shen Q, Ma X, Liu H, Li X, Shao W•
PubMed

Dupilumab in Atopic Dermatitis - Rate of Poor Responders and Potential Risk Factors from the TREATgermany Registry.

A distinct proportion of patients with atopic dermatitis and dupilumab treatment does not reach the primary endpoint of an eczema area severity index (EASI)-75 or investigator global assessment 0/1 after 16 weeks. Little is known about poor responders to dupilumab in real life scenarios. The study objective was to identify the percentage and characteristics of patients with insufficient treatment response to dupilumab based on “TREATgermany” registry data from dermatological routine care. Betwee...

Articles
Heratizadeh A, Naim J, Kind B, Loennecke K, Fischer S, Honstein T, Traidl S, Moennig E, Birkner T, Harder I, Mann C, Schaefer T, Abraham S, Augustin M, Ramaker-Brunke J, Pinter A, Meinhardt K, Quist S, Anders S, Schwarz B, Schulz-Kiesow M, Steinke S, Adler N, Handrick C, Schäkel K, Sticherling M, Bong A, Jacobs F, Großmann B, Stahl M, Buerkle CP, Gorriahn-Maiterth H, Biedermann T, Weidinger S, Schmitt J, Werfel T•
PubMed

Delayed Inflammatory Reaction to Periorbital Hyaluronic Acid Filler: Relapse After Lisinopril Withdrawal and Response to Retreatment.

Dear Editor, Hyaluronic acid (HA) fillers are widely used for facial and extrafacial rejuvenation and generally well tolerated [1]. Delayed inflammatory reactions (DIRs) may present with edema, erythema, induration, or nodules after an uneventful interval [1]. Their pathogenesis remains uncertain and may involve immune responses, filler degradation, and infectious or biofilm‐related factors; reported triggers include viral infections, sinusitis, dental procedures, different or low‐quality fille...

Articles
Bakay ÖSK, Gül B, Kaçar NG•
PubMed

Biomarker Testing, Imaging, and Outcomes in Cardiology-Referred Acute Breathlessness: A Retrospective Clinical Audit.

Background Breathlessness is a leading cause of emergency hospital attendances, and its multifactorial nature often reflects overlapping cardiopulmonary pathologies such as pulmonary embolism (PE), heart failure (HF), and acute coronary syndrome (ACS). Computed tomography pulmonary angiography (CTPA) is frequently used, often without documented pretest probability assessments. This audit primarily assessed the diagnostic yield of CTPA for suspected PE against the Royal College of Radiologists (...

Articles
Mathews J, Riaz RK, Kazi A, Rahman S•
PubMed

Correction: Multiplex PCR assay to detect high risk lineages of Salmonella Typhi and Paratyphi A.

Following the publication of this article [1], concerns were raised regarding Figs 2 and 3. Specifically, Figs 2 and 3 do not appear to match their corresponding captions. The second author stated that Figs 2 and 3 appear in the incorrect order in [1], that the gel image in Fig 2 in [1] should be Fig 3, and that the primer sequences in Fig 3 in [1] should be Fig 2. Please see the corrected figures below. The first author also stated that the gel image in Fig 2 in [1] is incorrect. The correct...

Articles
Khokhar F, Pickard D, Dyson Z, Iqbal J, Pragasam A, John JJ, Veeraraghavan B, Qamar F, Dougan G, MacQueen H, Rigas S, Holmes M, Mutreja A•
PubMed

Vibration-Controlled Transient Elastography (VCTE)-Based Prevalence and Assessment of Hepatic Steatosis and Fibrosis in a UK Tertiary Hospital-Based Specialist Weight Management Service: A Real-World Evaluation.

ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease is common in severe obesity; however, liver health assessment is inconsistently implemented in specialist weight management services and real‐world data are scarce. This study evaluated the prevalence and severity of vibration‐controlled transient elastography (VCTE)‐defined hepatic steatosis and fibrosis risk in adults attending a UK‐based Tier 3 specialist weight management service, and explored associations with cl...

Articles
Willis SA, Ahsan M, Rathi K, Lawrence I, Davies MJ, Webb DR, King JA, Ahmad E•
PubMed

Development of shelf-stable reagents and assay kits for bioluminescence applications using the capillary-assisted vitrification platform stabilization technology.

Luminescence is a powerful method for detecting trace analytes and monitoring biological processes. However, most bioluminescence reagents, including luciferase and its substrates, are sensitive to temperature, limiting their usable shelf lives, and resulting in inconsistent performance. Enhancing the stability of these reagents could reduce signal variability between experiments, simplify workflows, and address cold chain storage issues. In this study, we demonstrate the application of the plat...

Articles
Radford S, Peris-Taverner Y, Dibble M, Corn K, Zhu T, Martello S, Mayeaux M, Ladd A, Renu S, Chunduri T, Jadhav A, Dart M, Rafat M, Shank-Retzlaff M, Bronsart LL•