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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 13–24 of 2,098 articles

PubMed

Network changes in psychopathological symptoms following cognitive behavioral therapy for social anxiety disorder: evidence from 29 university outpatient clinics.

While network theory posits that interactions between social anxiety symptoms perpetuate social anxiety disorder (SAD), findings on how these networks change following treatment remain inconsistent. This study used data from 29 university outpatient clinics in Germany to estimate psychopathological symptom networks for patients with SAD at pre-treatment, explore critical symptoms and connections in pre- and post-treatment networks, and identify network changes in remitted vs. non-remitted patien...

Articles
Wen X, Velten J, Christiansen H, Hoyer J, In-Albon T, Lincoln TM, Lutz W, Rubel JA, Schwartz B, Stark R, Werheid K, Willutzki U, Bartholdy S, Berger EM, Bräscher AK, Forkmann T, Glombiewski JA, Hehlmann M, Helbig-Lang S, Hermann A, Hermann C, Kirsch A, Klucken T, Lueken U, Michael T, Odyniec P, Pedersen A, Pittig A, Renneberg B, Risch AK, Rudolph A, Scholten S, Schweden T, Teismann T, Vehlen A, Wilz G, Margraf J•
PubMed

Conceptualizing the process of experiential acceptance during an episode of anxiety: A qualitative study of individuals with prior experience in mindfulness- and acceptance-based interventions.

Introduction Experiential acceptance refers to the capacity to be open to internal experiences without attempting to change or avoid them. Although acceptance is a core emotion regulation strategy within mindfulness- and acceptance-based interventions (MABIs) and a protective factor for mental health, its conceptualization and implementation remain unclear and ambiguous. The aim of this study was to clarify and develop a model of accepting anxiety as experienced by individuals with prior experi...

Articles
Ribeyron J, Duriez N, Shankland R•
PubMed

Mathematical modeling and optimal control of immune responses in multiple sclerosis.

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated destruction of the myelin sheath in the central nervous system. In this work, we develop and analyze a mathematical model describing the interactions among myelin, autoreactive immune cells, regulatory immune cells, and treatment. A fast-time reduction of the slow–fast model yields an analytically tractable immune subsystem that captures the principal immune interactions. We establish the existence and stabi...

Articles
Al-arydah M•
PubMed

Retraction: Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone –induced multiple sclerosis model.

Following the publication of this article [1], the corresponding author requested a correction to Fig 6C and 6D, after concerns were raised about unusually repetitive features appearing in these panels. The corresponding author stated that internal microscope-generated labels were removed from the Fig 6C and 6D image by covering the labelled areas with a portion of the adjacent image. They provided what they described as an original unedited image underlying Fig 6D, and a re-stained and reimaged...

Articles
The PLOS One Editors•
PLOS

HIF-1α expression is associated to cell proliferation and ECM production in temporomandibular joint osteoarthritis

Temporomandibular joint osteoarthritis (TMJOA) is a complex joint disorder characterized by progressive degradation of the cartilage matrix and apoptosis of chondrocytes; however, hypoxia-inducible factor 1α (HIF-1α) serves a positive role in maintaining the stability of the articular cartilage matrix. Therefore, the present study aimed to determine the expression levels of HIF-1α in the cartilage tissue of rats with TMJOA, and to explore its association with the proliferation of chondrocytes an...

Articles
Li Liu, Xiaoying Shi, Xingxing Li, Yunhong Lin, Hefeng Yang, Jun Zhang, Chun Yang•
PLOS

Illness perceptions among adults aged 18–44 years with ankylosing spondylitis: A qualitative study informed by the common-sense model of self-regulation

Background: Ankylosing spondylitis mainly affects people in early and middle adulthood. This period involves important transitions in education, career, relationships, and family. Illness perceptions play an important role in treatment adherence and disease management. Few qualitative studies have examined how Chinese adults perceive and cope with the disease using a clear theoretical framework. Objective: This study aimed to explore illness perceptions among adults aged 18–44 years with ankylos...

Articles
Di Zhu, Binbin Wang, Yingjin Li, Xiaohan Nie, Haining Yin, Saisai Huang, Qiong Wang, Renju Xu•
PLOS

Laboratory-based assessment of quantitative PCR to describe Arctic fish assemblages in surface water affected by acid rock drainage

Permafrost thaw has been identified as a cause of metal mobilization from acid rock drainage and transport to Arctic rivers. Elevated metal concentrations and precipitation of Fe(III) minerals (i.e., rusting) in surface waters deteriorates water quality and raises questions about ecosystem effects, especially to the health of fish species. Environmental DNA (eDNA) analyses could be used for assessing impacts of acid rock drainage to fish assemblages but may be prone to biases like polymerase cha...

Articles
Laura C. Scott, Andrew M. Ramey, Ann E. Riddle-Berntsen, Brett A. Poulin, Joshua C. Koch, Jonathan A. O’Donnell, Michael P. Carey•
PLOS

Traditional knowledge of childhood illnesses among the Sidama nation, clinical presentation and hematological findings

Background: Sidama possesses extensive indigenous knowledge regarding infant illnesses described as “feyancho”. Feyancho has a widespread recognition among Sidama people, though poorly documented in scientific literature. This study aimed to document the indigenous understanding of this infantile disease and examine associated clinical and biochemical profiles in the Sidama National Regional State, Ethiopia. Methods: A household-based cross-sectional study was conducted in nine districts selecte...

Articles
Serawit Deyno, Mairegu Daniel, Tsadiku Getachew, Menfese Tadesse, Hizkel Engiso, Sintayehu Fekadu, Nigatu Tuasha•
PLOS

Associations of palmar surface lactic acid with hand scaling and in vitro pathogen inactivation: A cross-sectional study

The relationship between palmar surface lactic acid and hand scaling is not well understood. This cross-sectional study examined associations between palmar surface lactic acid, hand scaling, and in vitro anti-pathogenic activity, to generate hypotheses relevant to hand skin condition and pathogen inactivation. In 49 healthy adults, after standardized hand washing and acclimation (20°C, 40% RH), we assessed scaling (visual score), surface lactic acid and stratum corneum ceramides (LC–MS), stratu...

Articles
Kenichi Nagano, Kenji Manabe, Ichiro Mori, Yasuhiro Okada, Eri Shimizu, Satoru Naito•
PLOS

MFMNet: Adaptive tri-layer graph pyramid with cross-scale attention router for synergistic drug prediction

Background and objective: Experimental screening of synergistic anticancer drug pairs is time-consuming, while effectively integrating complementary molecular graph representations with cell-line-specific information remains challenging for computational drug-synergy prediction. Methods: We developed MFMNet with a Tri-Layer Graph Pyramid (TGP) comprising GCN, GIN, and GAT branches for extracting complementary molecular graph representations. A Cross-Scale Attention Router (CSAR), implemented as...

Articles
Lei Wang, Liping Sun, Jingwen Pan, Guangming Shao, Guokun Shi, Guanyu Zhang, Yucheng Shi, Li Jin•