Sign in Register

Clinical intelligence & editorial.

Advertisement

Advertisement

Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 349–360 of 2,098 articles

PubMed

Beyond Weight Loss: Effects of Semaglutide on Knee Pain, Physical Function, and Thigh Skeletal Muscle Volume in Obesity-Associated Knee Osteoarthritis.

Abstract Introduction: Obesity is an important modifiable risk factor for knee osteoarthritis, contributing to pain, functional limitation, and systemic inflammation. Semaglutide may provide benefits beyond weight reduction, but its effects on clinical and functional outcomes in obesity-associated knee osteoarthritis remain insufficiently characterized. Against this background, this study sought to evaluate the effects of 6-month semaglutide treatment on weight, knee pain, physical function, t...

Articles
Kumar BA, Sundaresan N, Syal A, AlSaifi MS, Krishnan BG, Mohanakrishnan B•
PubMed

Staphylococcus aureus-derived xanthine exacerbates allergic rhinitis-induced olfactory dysfunction through promoting Th17 cell differentiation and IL-17A production.

Abstract Objectives Allergic rhinitis (AR) is frequently accompanied by olfactory dysfunction (OD), yet the role of microbial metabolites in this process remains poorly elucidated. This study aimed to investigate how xanthine, a metabolite derived from Staphylococcus aureus (Sa), exacerbates AR‐induced OD by promoting Th17 cell differentiation and IL‐17A production. Methods Multi‐omics analyses, comprising metabolomics, proteomics and 16S rRNA gene sequencing, were performed on AR patients a...

Articles
Hu Y, Wang W, Yang T, Song X, Wang Y, Cheng Y, Mou Y, Ren C, Song X•
PubMed

A Current Evidence Review From the Italian Society of Pediatric Allergology and Immunology (SIAIP) on Practical Management of Allergic Rhinitis in Children and Adolescents.

ABSTRACT Background Allergic rhinitis (AR) is highly prevalent in children and adolescents and impairs quality of life, sleep, and school performance, while also worsening asthma control. The last EAACI position paper on pediatric AR was published in 2013. Significant scientific advancements, including the new ARIA 2026 guidelines, necessitate an updated national framework. Objectives This Italian Society of Pediatric Allergology and Immunology (SIAIP) document aims to provide an evidence‐ba...

Articles
Ciprandi G, Licari A, Indolfi C, Manti S, Giudice MMD, Tosca MA, Zicari AM, Marseglia G•
PubMed

Therapeutic Processes in Virtual Reality-Based Avatar Therapy for Treatment-Resistant Major Depressive Disorder: A Qualitative Analysis of Patients' Experiences.

ABSTRACT The therapeutic benefits of virtual reality‐based avatar therapy (VRT) compared with conventional psychotherapies remain unknown in individuals with treatment‐resistant major depressive disorder (TRD). Accordingly, this study aimed to explore patients' lived experience of VRT to identify perceived therapeutic processes and benefits, better understand how virtual reality and dialogue with an avatar contribute to therapeutic change and examine how these experiences differed from those as...

Articles
Giguère S, Daianska A, Nabalma S, Veillette F, Phraxayavong K, Potvin S, Dumais A•
PubMed

Circ_0018814 promotes the osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis by regulating the miR-944/KLF4 axis.

Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints. This study investigated the impact of circ_0018814 on the osteogenic differentiation of mesenchymal stem cells (MSCs) in AS through the regulation of the miR-944/KLF4 axis and to evaluate its potential role in the progression of AS. GSE203155 was used as an exploratory screening dataset to identify candidate circRNAs associated with osteogenic differentiation in AS-MSCs. Circ_001881...

Articles
Chen X, Xie J, Li Y, Chen X, Liu Y, Guo D•
PubMed

Upadacitinib as a rescue therapy for steroid- and infliximab-refractory acute severe ulcerative colitis: short- and long-term effectiveness and safety in a multicenter cohort study.

Abstract Background Acute severe active ulcerative colitis (ASUC) often requires rescue therapy when standard medical treatment fails. Data on the use of upadacitinib (UPA) as a rescue option after failure of steroids and infliximab (IFX) and on the long-term outcomes of UPA treatment up to 48 weeks, remain scarce. Methods We evaluated hospitalized patients with ASUC (Truelove and Witts criteria) who received UPA following the failure of intravenous corticosteroids (IV-CS) and IFX. Outcomes...

Articles
Ünal NG, Bakkaloğlu OK, Kav T, Eşkazan T, Kani HT, Akpınar A, Akıncıoğlu P, Dağcı G, Şendur İ, Büyüktorun İ, Barutçu S, Kılıç G, Bengi G, Çavuş B, Oruç N, Alahdab YÖ, Atuğ Ö, Dinçer D, Karakan T, Hatemi Aİ, Erzin YZ, Tezel A, Törüner M, Akyüz F, Çelik AF•
PubMed

Subcutaneous Furosemide for Ambulatory Decongestion in Heart Failure: Outcomes From a High-Risk Real-World Cohort.

ABSTRACT Background Volume overload remains a primary driver of heart failure hospitalization (HFH). Diuretic resistance limits the efficacy of oral loop diuretics during decompensation, often necessitating intravenous therapy. Subcutaneous (SC) furosemide (Furoscix, 80 mg/10 mL) represents a novel outpatient alternative for patients who remain symptomatic despite oral diuretic therapy. Objectives To evaluate the clinical outcomes of SC furosemide in ambulatory heart failure (HF) patients in...

Articles
Jafar O, Harper A, Toepp A, Yehya A•
PubMed

Protective Effects of Vitamin E and Selenium Nanoparticles Against Mercury Induced Growth, Blood and Histopathological Changes in Tilapia, Oreochromis niloticus.

ABSTRACT Introduction Heavy metal pollution, especially from mercury (Hg), poses a significant risk to the aquatic organisms. The present study examined the effectiveness of dietary selenium nanoparticles (SeNP) or vitamin E in mitigating mercury‐induced physiological effects including growth and feed utilisation, blood biochemical indices, histopathological changes in gills and intestine in Nile tilapia, Oreochromis niloticus. Materials and Methods After 15 days of acclimation, 20 fingerlin...

Articles
Ananna MA, Dash A, Hossain AA, Amin MR, Shahjahan M, Al-Emran M•
PubMed

Correction: STudy of Atropine to Reduce (STAR) Myopia Progression in Children: 24-Month Results of a Randomized, Double-Masked, Vehicle-Controlled Trial of Atropine Sulfate 0.01% and 0.03.

Correction: Ophthalmology and Therapy (2026) 15:1685–1703https://doi.org/10.1007/s40123-026-01341-0 In this article, in the PLAIN LANGUAGE SUMMARY section, a sentence was incorrect which previously appeared as“Children receiving atropine 0.01% had 0.13 diopters less myopia worsening at 2 years than those receiving vehicle, while those using atropine 0.03% had 0.12 diopters less worsening.” But should have been“Children receiving atropine 0.01% had 0.13D/year less myopia worsening at two years...

Articles
Korenfeld M, Hurcikova M, Tatsuoka K, Tomciková D, Cheetham J, Kacerik M, STAR Study Investigators•
PubMed

Correlation between phenotypic disc diffusion test and PCR molecular test for detection of methicillin resistance in Staphylococcus epidermidis and Staphylococcus hominis.

Abstract Introduction. Coagulase-negative staphylococci (CoNS), particularly Staphylococcus epidermidis, are leading opportunistic pathogens in neonatal intensive care units, frequently associated with late-onset sepsis and medical device colonization. Gap statement. Cefoxitin disk diffusion has been adopted internationally as a surrogate marker for mecA, but its accuracy in CoNS is heterogeneous; high resistance rates and erratic phenotypic expression in species like Staphylococcus hominis in...

Articles
Gonzalez-Lopez L, Morelos-Ramirez R, Cabrera R•
PubMed

Steric nested AS-PCR detects SNP in the W1282X-CFTR allele with endpoint thermal cycler.

Abstract To develop a cost‐effective approach, allele‐specific and nested polymerase chain reaction (PCR) techniques were combined with a steric hindrance destabilization strategy to improve discrimination of DNA samples positive for W1282X‐CFTR using an affordable endpoint PCR thermal cycler. Using Yaku's steric strategy, forward primers contained a deliberate mismatch near the mutation site. We hypothesized that these allele‐specific primers could selectively amplify DNA containing the W1282X...

Articles
Torok JA 4th, Brown DL, Grassl MR, Vijayakumar S, Patel KP, Jehangir A, Katti J, Barnas DF 2nd, Dooley LP, Dhar A, MacDougall CA, Ciacci RJ, Torres SR, Katrib N, Luckie D•
PubMed

American Academy of Pain Medicine consensus guidelines on neuromodulation technologies and neurocomputer interfaces for pain management and functional recovery.

Abstract Objective To provide an evidence-based framework for healthcare professionals to use neuromodulation technologies to restore neuromuscular function and relieve pain. Methods An expert panel, convened by the American Academy of Pain Medicine Foundation, conducted a literature review of English-language studies published between 2015 and 2025 using PubMed, the Cochrane Library, Web of Science, and Scopus (detailed in Supplementary Material S2). The panel screened abstracts, extracted...

Articles
Emerick T, Vorenkamp KE, Francio VT, Srinivasan S, Singla P, Castellanos J, Ahadian FM, Chen Z, Gianlorenco AL, Sarno D, Sehgal N, Murthy N, Barreveld AM•