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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 373–384 of 2,098 articles

PubMed

Patient-Spouse Experiences of Post-Stroke Life Reconstruction: A Longitudinal Dyadic Journey Mapping Study.

Abstract Background Young and middle‐aged stroke survivors with residual limb motor impairment continue rehabilitation while resuming employment, family responsibilities, and social roles. Their spouses often provide care and rehabilitation support, yet little is known about how partners’ experiences compare and change within dyads over time. This study aimed to examine the experiences of young and middle‐aged stroke survivors with limb motor impairment and their spouses across inpatient recov...

Articles
Li W, Ye Q, Zhang H, Wang M, Fan Y, Li Q•
PubMed

Transesophageal Endoscopic Ultrasound With Bronchoscope-Guided Fine-Needle Aspiration for Tissue Diagnosis of Pleural Malignancy in a Patient With Respiratory Compromise.

ABSTRACT Histologic confirmation is essential in suspected pleural malignancy, particularly for subtype classification and molecular profiling. However, conventional diagnostic approaches, including thoracoscopic, percutaneous, and airway‐based bronchoscopic biopsy, may be difficult or high‐risk in patients with severe respiratory compromise or poor pulmonary reserve. Endoscopic ultrasound with bronchoscope‐guided fine‐needle aspiration (EUS‐B‐FNA) is not a standard diagnostic modality for pleu...

Articles
Kim SY, Chung C, Park D•
PubMed

Glucomannan From Acrocomia corumbaensis (Bocaiuva) Attenuates Pain and Inflammation in DSS-Induced Colitis via Mucus Barrier Protection.

ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by weight loss, abdominal pain, diarrhoea and rectal bleeding. Polysaccharides have recognized protective and immunoregulatory effects in the gut. This study investigated BFS, a glucomannan extracted from bocaiuva, in dextran sulphate sodium (DSS)‐induced colitis. Male and female C57BL/6J mice received 3% DSS and BFS (1, 10, or 100 mg/kg, orally) for 7 days. Disease activity index (DAI) was monitored daily, w...

Articles
Brito MSC, Taporosky AK, Rech KS, Santos LBS, Gois MB, de Souza LFN, de Freitas RA, Azevedo CAB, Mathias C, Cordeiro LMC, Werner MFP•
PubMed

Integrative Genetic and Single-Cell Analysis Reveals Macrophages as Key Mediators Linking Aging and Osteoporosis.

ABSTRACT Osteoporosis is a highly prevalent age‐related disorder, and accumulating evidence suggests that it does not arise in isolation but is intrinsically linked to the aging process. Here, we employed integrative methods to systematically identify the relationship between aging and osteoporosis, and uncover the critical cell types and molecular regulators that mediate this association. Observational analysis of phenotypic data from UK Biobank and Mendelian Randomization analysis of summary‐...

Articles
Li X, Yang MY, Gai SR, Wei P, Gu ZH, Han MY, Wu YZ, Yu JS, Chen WJ, Liao ZR, Gu JX, Zhong JD, Zhao PP, Zhu K, Cheung CL, Karasik D, Zheng HF•
PubMed

Effectiveness and Safety of Once-Weekly Semaglutide 2.4 mg in Korean Adults With Obesity or Overweight: A Multicenter Retrospective Real-World Study (RE-SEMA-K Study).

ABSTRACT Aims To evaluate the effectiveness and treatment patterns of once‐weekly semaglutide 2.4 mg in South Korean adults with overweight or obesity in real‐world practice. Materials and Methods This multicenter retrospective study analysed electronic medical records from 17 centres in South Korea. Included were adults (≥ 19 years) with BMI ≥ 25 kg/m2, or ≥ 23 kg/m2 with obesity‐related comorbidities. Primary endpoints were changes in body weight at 3, 6, 9, and 12 months. Secondary outcom...

Articles
Kwon YJ, Kim YS, Ko HJ, Jung S, Cho YJ, Song JE, Lee SB, Nam GE, Park J, Seo MJ, Kim JK, Kang SY, Yoon YS, Cho SH, Kim Y, An HJ, Kim SH, Seo YB, Lee YH, Heo SJ, Kang JH, Kim KK•
PubMed

Correction: Women's Treatment Preferences for Moderate to Severe Vasomotor Symptoms Associated with Menopause: Insights from the WARMER Study.

Correction: The Patient - Patient-Centered Outcomes Researchhttps://doi.org/10.1007/s40271-026-00831-4 In the sentence beginning ‘The mean (standard deviation) age…’ in this article, the value ‘4.53’ should have read ‘5.34’. The correct sentence should read as follows: The mean (standard deviation) age was 54.9 years (5.34), most women (67.5%) were living with a partner, 44.2% had a university degree and 47.5% worked full-time. The original article has been corrected.

Articles
Heidenreich S, Simoncini T, Cutts K, Krucien N, Kim J, Todorova L, Walker J, Kristjansson C, Hillard T•
PubMed

Synbiotic Kefir-Yacon Drink Ameliorates Hypertension by Modulating Antioxidant and Anti-Inflammatory Pathways.

ABSTRACT Hypertension is associated with oxidative stress, chronic inflammation, and gut microbiota dysbiosis. This study evaluated whether a fermented kefir‐yacon synbiotic beverage could improve hemodynamic parameters in a hypertension model through its antioxidant, anti‐inflammatory, and gut microbiota‐modulating effects. Spontaneously hypertensive rats (SHR) and Wistar rats were divided into four groups: Wistar treated with vehicle (W), SHR treated with vehicle (SHR), SHR treated with unfer...

Articles
Moraes FSA, Fragoso MC, da Silva CL, Dutra KA, Gonçalves LGDS, Campelo LA, Melo Junior AF, Bissoli NS, Amorim GAB, Lima EM, Andrade TU•
PubMed

Acute sprint exercise transcriptome in adipose tissue of healthy adults: Associations with growth hormone.

Abstract We hypothesised that acute sprint exercise induces changes in adipose tissue (AT) gene expression related to lipolysis, and that growth hormone (GH) contributes to this. Healthy males and females were randomised to perform 3 × 30‐s all‐out cycle sprints (SIT, N = 12) or unloaded cycling (CON, N = 6). AT‐biopsies were performed before and 2 h after exercise. Serum GH‐response was greater following SIT than CON, but no SIT‐specific enrichment of lipolysis‐related genes was found in a gen...

Articles
Esbjörnsson M, Rundqvist HC, Norman B, Österlund T, Bülow J, Jansson E•
PubMed

Efficacy and Safety of Datopotamab Deruxtecan From a Single-Institution Experience in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer After Multiple Prior Therapies Including Antibody-Drug Conjugates.

ABSTRACT Background Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell surface antigen 2 (TROP2)–directed antibody–drug conjugate (ADC) with a topoisomerase I inhibitor payload and was approved by the Japan Pharmaceuticals and Medical Devices Agency in 2025 for patients with unresectable or recurrent hormone receptor–positive (HR+)/human epidermal growth factor receptor 2–negative (HER2−) breast cancer previously treated with chemotherapy. In the pivotal TROPION‐Breast01 trial, most patie...

Articles
Shimada H, Todo M, Ishiguro H, Mikami E, Inohana W, Kurosawa T, Nakame A, Sakakibara A, Ichinose Y, Fujimoto A, Nukui A, Asano A, Yokogawa H, Ohara M, Matsuura K, Hasebe T, Fujiuchi N, Osaki A, Saeki T•
PubMed

A plasma proteomic frailty signature for cardiovascular risk stratification: A multi-cohort study.

Background Frailty predicts adverse health outcomes, but its relationship with cardiovascular disease (CVD) requires further validation across diverse populations. The value of a circulating protein signature for cardiovascular risk assessment remains uncertain. Methods We examined frailty–CVD associations in the XiDu2017 cohort (n = 4323) and UK Biobank (UKB; n = 84,276) using logistic and Cox regression, respectively. XiDu longitudinal analyses included 844 participants without baseline CVD...

Articles
Zheng P, Wu J, Gu X, Yu Y, Fan X, Wang G, Yan W, Gu G, Chen Z, Tian Z, Zhang Y, Gu J, Qian J, Ge J•
PubMed

Integrated Multi-Omics Analyses Reveal Causal DNA Methylation-Breast Cancer Associations Mediated by Plasma Proteins.

ABSTRACT Although aberrant DNA methylation is implicated in breast cancer (BC) pathogenesis, establishing causality is difficult and the downstream mediators are unclear. We investigated the causal role of blood DNA methylation and its proteomic mediators. Differentially methylated positions (DMPs) were identified from a genome‐wide blood methylation dataset, and two‐sample Mendelian randomization (MR) was performed using methylation quantitative trait loci for the significant DMPs together wit...

Articles
Wang W, Cheng Z, Liu R, Cheng X, Chen H•
PubMed

Developing Machine Learning-Based Prognostic Models for Nonmelanoma Skin Cancer Patients With Comorbid Diabetes: A Retrospective Cohort Study.

ABSTRACT Background Nonmelanoma skin cancer (NMSC) is one of the most common malignancies worldwide, with increasing incidence. Type 2 diabetes mellitus (T2DM) is a prevalent comorbidity that may adversely affect cancer prognosis through shared metabolic and inflammatory pathways. This study aims to identify risk factors influencing the survival of NMSC patients with T2DM, construct and evaluate the performance of different predictive models, and develop a comprehensive risk score to accuratel...

Articles
Huang J, Zhong CC, Li Z, Yang Z, Jiang Y, Yuan J, Poon J, Dou Q, Wong MCS•