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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 457–468 of 2,098 articles

PubMed

Efficacy and safety of duloxetine for osteoarthritis: a comparator-stratified systematic review and meta-analysis.

Summary Background Duloxetine is recommended for osteoarthritis pain, yet its role relative to placebo, active pharmacological comparators, and add-on therapy remains uncertain. We assessed the efficacy and safety of duloxetine for osteoarthritis using a comparator-stratified meta-analysis. Methods We searched major English and Chinese databases from inception to August 30, 2026, for randomised controlled trials of duloxetine in adults with osteoarthritis. Eligible trials compared duloxetine...

Articles
Zhang D, Shahid A, Zhang G, Xin B, Deveza LA, Venkatesha V, Hunter DJ•
PubMed

Allergen Spectrum and House Dust Mite Component-Resolved Sensitization Patterns in Children with Allergic Rhinitis: A Two-Stage Study.

Background House dust mite (HDM) is the predominant indoor allergen in children with allergic rhinitis (AR), but conventional binary reporting obscures both sensitization intensity and component-specific profiles. Methods This two-stage retrospective cross-sectional study enrolled 2036 children (1–15 years) with AR. Serum sIgE against 19 allergens was measured by immunoblot (≥0.35 kU/L positive). D. pteronyssinus-positive samples were stratified into six sensitization grades. In Stage 2, 110...

Articles
Xu X, Ye C, Chen D, Xiao X, Wang Z, Zhao X•
PubMed

Characterizing acute ischemia via ECG: A study of severity, extent, and spatial variability in myocardial infarction and non-infarction groups.

Ischemic heart disease remains the leading cause of mortality worldwide. Its diagnosis largely relies on detecting dynamic changes in the ST segment of the electrocardiogram (ECG). However, alterations in other ECG waves and intervals have also been reported. One factor that is often overlooked is the presence of a prior myocardial infarction and its influence on the myocardial response to a new ischemic event. This study aimed to quantify the magnitude and temporal dynamics of ECG changes durin...

Articles
Rodríguez-Carbó J, Mincholé A, Pueyo E•
PubMed

ECG interpretation in athletes by expert sports cardiologists and nonspecialist medical professionals across Europe: a survey from the European association of preventive cardiology.

Abstract Aims We aimed to evaluate the real-world use of contemporary international ECG interpretation criteria in athletes, and to compare practices, clinical decision-making, and perceived barriers between specialist and nonspecialist professionals across Europe. Methods and results Two sets of structured questionnaires were developed and distributed to either sports cardiologists or nonspecialist professionals. Knowledge of international guidelines, experience in ECG interpretation, and c...

Articles
Androulakis E, MacLachlan H, Cavarretta E, Vassiliou VS, Antonakaki D, Friebel R, Kebede M, Bhatia R, Gati S, Finocchiaro G, Papadakis M, Castelletti S, D'Ascenzi F•
PubMed

The PCOS-to-PMOS shift in the broader history of nomenclature changes and its uncertain impact on clinical practice.

Abstract Proposed renaming of polycystic ovary syndrome (PCOS) to polyendocrine metabolic ovarian syndrome (PMOS) aims to broaden multidisciplinary care. However, it may obscure reproductive manifestations and introduce phenotypic ascertainment bias. Historical examples of nomenclature changes suggest that clinical benefits depend heavily on diagnostic, therapeutic, and etiological advances and education. Although formal cost‐effectiveness analysis of nomenclature changes are lacking, our preli...

Articles
Aleksejeva-Zagura E, Laudański P, Acharya G, Salumets A•
PubMed

The social roots of student mental health: Organizational opportunity structures, social capital, and loneliness.

Background Individual and clinical approaches to student mental health can obscure the role of universities as social environments. Within a social-capital framework, we examine whether loneliness links peer integration and student–faculty relationship quality to later psychological distress. Methods Three waves of the German National Educational Panel Study (NEPS SC5; N = 3014 enrolled students) linked relationship measures (2012) to loneliness (2013/2014) and psychological distress measured...

Articles
Voss G, Pohlenz P•
PubMed

Knowledge, attitude, and practice regarding menopause management among primary healthcare providers in Kelantan, Malaysia: A cross-sectional study.

Abstract Introduction: Menopause marks the end of a woman’s reproductive years. Primary healthcare providers (PCPs) play a pivotal role in identifying menopausal symptoms, providing counselling and initiating management. However, information on their knowledge, attitudes and clinical practices in Malaysia remains limited. This study aimed to assess the knowledge, attitudes and practices regarding menopause management among PCPs in Kelantan. Methods: A cross-sectional study was conducted amon...

Articles
Che Ibrahim NH, Ng YY, Muhammad J, Draman N•
PubMed

Aerobic and muscle-strengthening guideline adherence and mobility limitation among adults with arthritis in the United States: a pooled cross-sectional analysis, 2020-2024.

Objective To compare mutually exclusive leisure-time aerobic and muscle-strengthening guideline-adherence patterns in relation to mobility limitation among U.S. adults with doctor-diagnosed arthritis. Methods We pooled cross-sectional data from the 2020, 2022, and 2024 National Health Interview Survey in the United States for adults aged 18 years or older with doctor-diagnosed arthritis. Leisure-time activity was classified as neither guideline met, muscle-strengthening only, aerobic only, or...

Articles
Wang D, Tian J, Peng Y, Wu S, Feng Y•
PubMed

Single-dose/day versus extended antibiotic prophylaxis for elective urological surgery: a prospective randomized controlled trial.

Summary Background Excess and prolonged antibiotic use for perioperative prophylaxis is a very common clinical practice. This overuse is largely driven by ingrained protocols rooted in fear of postoperative infection, despite limited evidence supporting extended prophylaxis. The objective was to evaluate whether extending antibiotic prophylaxis beyond the immediate perioperative period provides additional protection against postoperative symptomatic urinary tract infection (UTI) in patients un...

Articles
Nayyar R, Shetty RS, Kushwaha A, Mahapatra S, Panaiyadiyan S, Singh P, Jain S, Kumar M, Kumar S, Nayak B, Seth A•
PubMed

Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation.

Summary Background The effect of timely appropriate antibiotics in multidrug-resistant Gram-negative bacteria (MDR-GNB) bloodstream infections (BSIs) remains uncertain. Robust evidence is needed to inform diagnostic and treatment strategies, especially across settings with high antimicrobial resistance (AMR) and varying access to effective preventive and treatment therapeutics. Methods Using data from the prospective ACORN-HAI cohort across 19 Asian countries between September 2022 and Febru...

Articles
Mezzadri L, Tan WC, Hao X, Quah J, Manesh A, Chang YT, Nguyen ATK, Ding Y, Kitsaran S, Chua HH, Bory S, Ponnampalavanar S, Anunnatsiri S, Mazlan MZ, Dhiloo AK, Plongla R, Lay-Hoon Kwa A, Mahmood SF, Roman AD, Thwaites CL, Tho PV, Wu S, Chotiprasitsakul D, Wong KJ, Wijaya H, Abad CL, Rehman Khalid MO, Salahuddin Mamun GM, Rajahram GS, Gutierres H, Hon HN, Van Giang T, Pham NT, Karkey A, Gunasekara S, Hamers RL, Sinto R, Lubis IND, Wang M, Moni M, Liu PY, Xiao Y, Khanal B, Priya NL, Doi Y, Honda H, Baljin B, Gurav U, Asli R, Ling L, Dhungana A, Hsu LY, Paterson DL, Mo Y, ACORN-HAI investigators•
PubMed

Serum neurofilament light chain and the 2024 McDonald criteria for multiple sclerosis: a retrospective cohort study.

Summary Background The 2024 McDonald criteria broaden the definition of multiple sclerosis (MS), enabling diagnosis in individuals with asymptomatic MRI findings or clinical presentations not meeting the 2017 criteria. We assessed whether these criteria identify such cases using independent laboratory/imaging biomarkers and whether these biomarkers predict subsequent disease activity. Methods Participants with asymptomatic MRI findings or clinical presentations not meeting the 2017 criteria...

Articles
Borrelli S, Barbuti E, Bayart JL, Deltombe M, Vanden Bulcke C, Stölting A, Guisset F, Tota V, Elands S, Ceccarelli A, Bugli C, El Sankari S, van Pesch V, Maggi P•
PubMed

"Threefold dual" copper homeostasis regulation strategy: Targeted copper surge for enhanced cancer immunotherapy.

Copper-based therapeutics disrupting intracellular copper homeostasis hold immense promise for cancer immunotherapy, yet their efficacy is severely limited by inadequate copper accumulation, intratumoral antioxidant defenses, and nonspecific drug release. To surmount these limitations, we engineered CuTF-DC_AC50, an innovative copper homeostasis nanomodulator implementing a "threefold dual" strategy to maximize therapeutic outcomes. Specifically, the nanomodulator drives massive copper overload...

Articles
Wang Q, Wang Q, Dong J, Zhou Y, Cui Z, Li B, Qu B, Zhang R•