Penicillin G Potassium (penicillin G potassium)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Penicillin G, a natural penicillin, is a beta-lactam antibiotic.
Penicillin G potassium and penicillin G sodium are used parenterally when rapid and high concentrations of penicillin G are required, as in the treatment of endocarditis, meningitis, pericarditis, septicemia, severe pneumonia, or other serious infections caused by organisms susceptible to penicillin G.
Generic name: penicillin G potassium
Pronunciation: (pen-ih-SILL-in GEE)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Penicillin G Potassium
Indications
The following indications are listed for Penicillin G Potassium:
- Abdominal Actinomycosis
- Actinomycosis
- Anthrax Septicemia
- Aspiration Pneumonia
- Botulism
- Cervicofacial Actinomycosis
- Clostridium Perfringens Empyema
- Congenital Neurosyphilis
- Cutaneous Anthrax
- Diphtheria
- Enterococcal Endocarditis
- Enterococcus Septicemia
- Erysipeloid
- Erysipelothrix Endocarditis
- Fusospirochetal Pharyngitis
- Gas Gangrene Caused By Clostridium Perfringens
- Gastrointestinal Anthrax
- Granulomatosis Infantiseptica
- Inhaled Anthrax
- Listeria Endocarditis
- Listeria Meningitis
- Lung Abscess
- Meningitis Due To Anthrax
- Meningococcal Meningitis
- Meningococcemia
- Necrotizing Fasciitis Streptococcus Infection
- Necrotizing Pneumonia
- Neonatal Group B Streptococcal Septicemia
- Neonatal Meningitis
- Neonatal Pneumonia
- Neurosyphilis
- Pasteurella Multocida Endocarditis
- Pasteurella Multocida Osteomyelitis
- Pasteurellosis
- Pneumococcal Meningitis
- Pneumococcus Endocarditis
- Primary Genital Syphilis
- Pulmonary Actinomycosis
- Rat-Bite Fever
- Scarlet Fever
- Secondary Syphilis
- Sepsis Of Newborn
- Skin And Skin Structure Streptococcus Pyogenes Infection
- Streptococcal Endocarditis
- Streptococcal Meningitis
- Streptococcal Pneumonia
- Streptococcal Toxic Shock Syndrome
- Streptococcus Empyema
- Streptococcus Myositis
- Streptococcus Pericarditis
- Symptomatic Congenital Syphilis
- Tetanus
- Upper Respiratory Infection Due To Neisseria Meningitidis
Also known as: Abdominal Actinomycotic Infection, Actinomycotic Infection, Actinophytosis, Anthracemia, Anthrax Meningitis, Anthrax Pneumonia, Bacterial Sepsis Of Newborn, Cerebral Anthrax, Cervicofacial Actinomycotic Infection, Clostridium Perfringens Gas Gangrene, Diphtheritis, Disseminated Infantile Listeriosis, Empyema Due To Clostridium Perfringens, Empyema Due To Streptococcus, Endocarditis Due To Enterococcus, Endocarditis Due To Erysipelothrix Rhusiopathiae, Endocarditis Due To Listeria Monocytogenes, Endocarditis Due To Pasteurella Multocida, Endocarditis Due To Streptococcus, Fusospirochetal Infection Of The Oropharynx, Gangrenous Erysipelas Due To Streptococcus, Gangrenous Pneumonia, Gas Gangrene Due To Clostridium Perfringens, Gi Anthrax, Infection Caused By Erysipelothrix Rhusiopathiae, Infectious Disease With Painful Voluntary Muscle Spasms, Inhalational Anthrax, Intestinal Anthrax, Intoxication With Clostridium Botulinum Toxin, Juvenile Neurosyphilis, Late Congenital Neurosyphilis, Lumpy Jaw, Meningeal Anthrax, Meningitis Due To Listeria Monocytogenes, Meningitis Due To Listeriosis, Meningococcal Septicemia, Myositis Due To Streptococcus, Necrotic Pneumonia, Necrotizing Erysipelas Due To Streptococcus, Necrotizing Fasciitis Due To Streptococcus, Neonatal Group B Streptococcal Sepsis, Neonatal Sepsis, Osteomyelitis Due To Pasteurella Multocida, Pasteurella Infection, Pericarditis Due To Streptococcus, Pneumococcal Endocarditis, Pneumonia Due To Streptococcus Species, Pneumonia Due To Streptococcus Spp., Pulmonary Abscess, Pulmonary Actinomycotic Infection, Pyogenic Bone Infection Due To Pasteurella Multocida, Pyothorax Due To Clostridium Perfringens, Pyothorax Due To Streptococcus, Rag-Sorter's Disease, Ragpicker's Disease, Ragsorter's Disease, Rat-Bite Disease, Scarlatina, Sepsis Due To Enterococcus, Septicemia Due To Anthrax, Septicemia Due To Enterococcus, Septicemia Due To Neisseria Meningitidis, Skin & Skin Soft Tissue Streptococcus Pyogenes Infection, Skin Infection Due To Bacillus Anthracis, Sodoku, Sokosho, Streptococcal Infection Of The Pericardium, Streptococcus Pneumoniae Meningitis, Streptococcus Species Empyema, Syphilitic Chancre, Syriac Ulcer, Thoracic Actinomycosis, Toxic Shock Syndrome Due To Streptococcus, Tss Due To Streptococcus, Uri Due To Neisseria Meningitidis, Vincent's Angina, Wool-Sorter's Disease, Wool-Sorter's Pneumonia, Woolsorter's Disease.
Dosing
Dosage of penicillin G potassium and penicillin G sodium usually is expressed in terms of penicillin G units, but also has been expressed as mg of penicillin G.
In patients with impaired renal function, doses and/or frequency of administration of penicillin G may need to be modified in response to the degree of impairment.
The manufacturers state that dosage of IM or IV penicillin G potassium or sodium should be adjusted in patients with severe renal impairment. These manufacturers and others recommend that patients with creatinine clearance less than 10 mL/minute per 1.73 m2 receive a loading dose of penicillin G using the usually recommended dose followed by 50% of the usually recommended dose given every 8-10 hours. In uremic patients with creatinine clearance greater than 10 mL/minute per 1.73 m2, the manufacturers and others recommend a loading dose of penicillin G using the usually recommended dose followed by 50% of the usually recommended dose given every 4-5 hours.
Alternatively, some clinicians suggest that if the usual dosing interval for penicillin G potassium or sodium in patients with normal renal function (creatinine clearance greater than 50 mL/minute) is every 6 or 8 hours, then the usual dose should be given every 8-12 hours in those with creatinine clearance of 10-50 mL/minute or every 12-18 hours in those with creatinine clearance less than 10 mL/minute.
Some clinicians suggest a maximum daily dosage of 4-10 million penicillin G units in adults with severe renal failure.
In patients with impaired hepatic function in addition to impaired renal function, further dosage reductions may be advisable.
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No dosing information is available for this tab.
Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
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There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Reproduction studies evaluating penicillin G in mice, rats, and rabbits have not revealed evidence of impaired fertility or harm to the fetus. Although experience with use of penicillins during pregnancy has not shown any evidence of adverse effects on the fetus, there are no adequate or controlled studies using penicillin G in pregnant women.
Some clinicians state that penicillin G is considered low risk and safe for use during pregnancy. The drug is included in the US Centers for Disease Control and Prevention (CDC) recommendations for the treatment of syphilis during pregnancy.
The manufacturers state that penicillin G potassium or sodium should be used during pregnancy only when clearly needed.
Penicillin G is distributed into milk. Some clinicians state that penicillin G is usually considered compatible with breast-feeding. The manufacturers and others state that penicillin G potassium or sodium should be used with caution in nursing women.
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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