Indication

Listeria meningitis

Listeria meningitis is an acute, severe bacterial infection of the central nervous system leptomeninges caused by the facultative intracellular pathogen *Listeria monocytogenes*. Read more about Listeria meningitis

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About Listeria meningitis.

Listeria meningitis is an acute, severe bacterial infection of the central nervous system leptomeninges caused by the facultative intracellular pathogen *Listeria monocytogenes*.

It primarily develops via hematogenous dissemination following the ingestion of contaminated food and disproportionately affects neonates, adults older than 50 years, pregnant women, and individuals with impaired cell-mediated immunity.

Pathophysiologically characterized by bacterial penetration of the blood-brain barrier and intense subarachnoid inflammation, clinical manifestations include fever, headache, altered mental status, and nuchal rigidity, frequently complicated by seizures, cranial neuropathies, or progression to meningoencephalitis and rhombencephalitis.

Cerebrospinal fluid analysis typically reveals an elevated opening pressure, marked pleocytosis with variable neutrophil or lymphocyte predominance, elevated protein, and hypoglycorrhachia.

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