Drug class

Antifungal - Azoles Systemic

Systemic azole antifungals are synthetic antimycotic agents administered orally or parenterally to manage invasive, mucosal, and endemic fungal infections. Read more about Antifungal - Azoles Systemic

131 drugs in this class 79 manufacturers

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Drugs in Antifungal - Azoles Systemic

Showing 10–18 of 131 drugs

FLUCONAZOLE

ANTIFUNGALS-SYSTEMIC · ORAL CANDIDIASIS ·+11
GREENSTONE LLC.

VORICONAZOLE

ANTIFUNGALS-SYSTEMIC · DISSEMINATED CANDIDIASIS ·+6
SANDOZ

VORICONAZOLE

ANTIFUNGALS-SYSTEMIC · DISSEMINATED CANDIDIASIS ·+6
MYLAN INSTITUTI

FLUCONAZOLE

ANTIFUNGALS-SYSTEMIC · ORAL CANDIDIASIS ·+11
Mylan Pharmaceuticals

FLUCONAZOLE

ANTIFUNGALS-SYSTEMIC · ORAL CANDIDIASIS ·+11
GLENMARK PHARMA

FLUCONAZOLE

ANTIFUNGALS-SYSTEMIC · ORAL CANDIDIASIS ·+11
GREENSTONE LLC.
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About Antifungal - Azoles Systemic.

Systemic azole antifungals are synthetic antimycotic agents administered orally or parenterally to manage invasive, mucosal, and endemic fungal infections.

They exert their therapeutic effect by inhibiting the fungal cytochrome P450–dependent enzyme 14-alpha-demethylase, which blocks the conversion of lanosterol to ergosterol, thereby disrupting fungal cell membrane stability and inhibiting cellular growth.

Clinically, these agents—primarily triazoles such as fluconazole, itraconazole, voriconazole, and posaconazole—serve as essential therapies for systemic candidiasis, invasive aspergillosis, cryptococcal meningitis, and endemic mycoses including blastomycosis, histoplasmosis, and coccidioidomycosis, as well as for antifungal prophylaxis in immunocompromised hosts.