Drug class

Antiperistaltic Agents

Antiperistaltic agents—frequently categorized as antimotility or antidiarrheal medications—are a therapeutic class designed to inhibit gastrointestinal smooth muscle contractions and decrease propulsive peristalsis. Read more about Antiperistaltic Agents

130 drugs in this class 65 manufacturers

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Drugs in Antiperistaltic Agents

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About Antiperistaltic Agents.

Antiperistaltic agents—frequently categorized as antimotility or antidiarrheal medications—are a therapeutic class designed to inhibit gastrointestinal smooth muscle contractions and decrease propulsive peristalsis.

By reducing bowel motility, these agents prolong intestinal transit time, which facilitates greater mucosal absorption of fluids and electrolytes to improve stool consistency and reduce evacuation frequency.

They are primarily indicated for the symptomatic management of acute non-specific diarrhea and chronic diarrhea associated with conditions such as irritable bowel syndrome or inflammatory bowel disease.

Certain antiperistaltic drugs are also utilized peri-procedurally during gastrointestinal endoscopy or abdominal magnetic resonance imaging to suppress motion artifacts and optimize visualization.