Drug class

Antithrombin Agents

Antithrombin agents encompass therapeutic formulations of antithrombin—a naturally occurring plasma glycoprotein and serine protease inhibitor—as well as direct antithrombin or thrombin-inhibiting therapies. Read more about Antithrombin Agents

164 drugs in this class 74 manufacturers

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Drugs in Antithrombin Agents

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About Antithrombin Agents.

Antithrombin agents encompass therapeutic formulations of antithrombin—a naturally occurring plasma glycoprotein and serine protease inhibitor—as well as direct antithrombin or thrombin-inhibiting therapies.

In therapeutic replacement, these agents function by binding to and inactivating thrombin and other activated clotting factors (such as factor Xa), a process markedly accelerated by heparin, thereby dampening the coagulation cascade and preventing thrombus formation.

In clinical pharmacology, they are primarily indicated for the treatment and prophylaxis of thromboembolism—particularly peri-operative and peri-partum venous thromboembolic events—in patients with hereditary antithrombin deficiency, and broadly serve as antithrombotic therapies across specialized thromboembolic disorders.