Antithyroid Agents

Antithyroid agents are an endocrine drug class primarily represented by the thionamides methimazole, carbimazole, and propylthiouracil

These medications work predominantly by inhibiting the thyroid peroxidase enzyme, thereby blocking the iodination of tyrosine residues and the subsequent synthesis of thyroxine and triiodothyronine Some agents within the class, such as propylthiouracil, also reduce the peripheral deiodination of thyroxine to its more active form

Some agents within the class, such as propylthiouracil, also reduce the peripheral deiodination of thyroxine to its more active form

Clinically, antithyroid agents are utilized to manage hyperthyroidism and thyrotoxicosis resulting from conditions such as Graves' disease or toxic multinodular goiter, and to achieve euthyroid control before thyroidectomy or radioactive iodine therapy

Clinically, antithyroid agents are utilized to manage hyperthyroidism and thyrotoxicosis resulting from conditions such as Graves' disease or toxic multinodular goiter, and to achieve euthyroid control before thyroidectomy or radioactive iodine therapy

Clinically, antithyroid agents are utilized to manage hyperthyroidism and thyrotoxicosis resulting from conditions such as Graves' disease or toxic multinodular goiter, and to achieve euthyroid control before thyroidectomy or radioactive iodine therapy