Antiviral-HIV(Antiretroviral) Nucleoside/-tide RT Inhibitors

Antiviral-HIV (antiretroviral) nucleoside and nucleotide reverse transcriptase inhibitors, commonly abbreviated as NRTIs or NtRTIs, are a foundational class of medications used in combination antiretroviral therapy

Antiviral-HIV (antiretroviral) nucleoside and nucleotide reverse transcriptase inhibitors, commonly abbreviated as NRTIs or NtRTIs, are a foundational class of medications used in combination antiretroviral therapy NRTIs serve as a cornerstone treatment backbone for human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2) infections, pre- and post-exposure prophylaxis against HIV, and, in certain cases, chronic hepatitis B virus (HBV) infection

These agents function as structural analogues of natural purine or pyrimidine deoxynucleosides, which require intracellular phosphorylation to become active and subsequently compete for incorporation into growing viral DNA strands Lacking an essential 3'-hydroxyl group, they inhibit the viral reverse transcriptase enzyme and cause premature chain termination, thereby halting the transcription of viral RNA into proviral DNA and preventing replication

Lacking an essential 3'-hydroxyl group, they inhibit the viral reverse transcriptase enzyme and cause premature chain termination, thereby halting the transcription of viral RNA into proviral DNA and preventing replication

NRTIs serve as a cornerstone treatment backbone for human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2) infections, pre- and post-exposure prophylaxis against HIV, and, in certain cases, chronic hepatitis B virus (HBV) infection