Beta-Adrenergic Agents Long-Acting (Inhaled)

Inhaled long-acting beta-adrenergic agents—commonly termed long-acting beta-agonists (LABAs)—are a therapeutic drug class of inhaled bronchodilators designed to provide sustained airflow maintenance Clinically, these agents are primarily indicated for the long-term maintenance management of chronic obstructive pulmonary disease (COPD) and persistent asthma

Inhaled long-acting beta-adrenergic agents—commonly termed long-acting beta-agonists (LABAs)—are a therapeutic drug class of inhaled bronchodilators designed to provide sustained airflow maintenance

They function by selectively stimulating beta-2 adrenergic receptors in bronchial smooth muscle, which activates intracellular adenylyl cyclase, increases cyclic adenosine monophosphate (cAMP), and produces prolonged airway smooth muscle relaxation typically lasting 12 to 24 hours

Clinically, these agents are primarily indicated for the long-term maintenance management of chronic obstructive pulmonary disease (COPD) and persistent asthma

In asthma therapy, however, clinical guidelines and regulatory authorities require that LABAs be co-administered with an inhaled corticosteroid rather than used as monotherapy

In asthma therapy, however, clinical guidelines and regulatory authorities require that LABAs be co-administered with an inhaled corticosteroid rather than used as monotherapy