Drug class

Bismuth Salts

Bismuth salts represent a class of gastrointestinal and antimicrobial agents composed of insoluble heavy-metal compounds, most notably bismuth subsalicylate and bismuth subcitrate potassium. Read more about Bismuth Salts

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About Bismuth Salts.

Bismuth salts represent a class of gastrointestinal and antimicrobial agents composed of insoluble heavy-metal compounds, most notably bismuth subsalicylate and bismuth subcitrate potassium.

They exert therapeutic effects locally in the gastrointestinal lumen by coating and protecting ulcerated mucosa, stimulating mucosal prostaglandin and bicarbonate production, and delivering direct bactericidal activity via bacterial cell wall disruption and enzyme inhibition.

In bismuth subsalicylate formulations, luminal hydrolysis also releases salicylate, which contributes antisecretory and anti-inflammatory activity.

Clinically, these agents are primarily indicated as core components of combination regimens for *Helicobacter pylori* eradication in peptic ulcer disease, as well as for the symptomatic treatment and prophylaxis of acute non-specific diarrhea, traveler's diarrhea, and dyspepsia.