Central Adrenolytics

Central adrenolytics, also widely known as centrally acting sympatholytics, are a class of cardiovascular agents that suppress sympathetic nervous system activity originating within the central nervous system These medications—most notably central alpha-2 adrenergic agonists such as clonidine, methyldopa, and guanfacine—stimulate presynaptic alpha-2 receptors or imidazoline receptors in the brainstem, thereby decreasing central sympathetic outflow, reducing peripheral vascular resistance, and lo...

Central adrenolytics, also widely known as centrally acting sympatholytics, are a class of cardiovascular agents that suppress sympathetic nervous system activity originating within the central nervous system These medications—most notably central alpha-2 adrenergic agonists such as clonidine, methyldopa, and guanfacine—stimulate presynaptic alpha-2 receptors or imidazoline receptors in the brainstem, thereby decreasing central sympathetic outflow, reducing peripheral vascular resistance, and lo...

These medications—most notably central alpha-2 adrenergic agonists such as clonidine, methyldopa, and guanfacine—stimulate presynaptic alpha-2 receptors or imidazoline receptors in the brainstem, thereby decreasing central sympathetic outflow, reducing peripheral vascular resistance, and lowering heart rate and blood pressure

These medications—most notably central alpha-2 adrenergic agonists such as clonidine, methyldopa, and guanfacine—stimulate presynaptic alpha-2 receptors or imidazoline receptors in the brainstem, thereby decreasing central sympathetic outflow, reducing peripheral vascular resistance, and lowering heart rate and blood pressure

Their primary therapeutic role is in managing hypertension, including resistant hypertension and hypertensive disorders of pregnancy, and selected agents also find therapeutic utility in neuropsychiatric conditions such as attention-deficit/hyperactivity disorder

Their primary therapeutic role is in managing hypertension, including resistant hypertension and hypertensive disorders of pregnancy, and selected agents also find therapeutic utility in neuropsychiatric conditions such as attention-deficit/hyperactivity disorder

Their primary therapeutic role is in managing hypertension, including resistant hypertension and hypertensive disorders of pregnancy, and selected agents also find therapeutic utility in neuropsychiatric conditions such as attention-deficit/hyperactivity disorder