Drug class

Cephalosporins - 1st Generation

First-generation cephalosporins are a therapeutic class of bactericidal beta-lactam antibiotics that include agents such as cefazolin, cephalexin, and cefadroxil. Read more about Cephalosporins - 1st Generation

70 drugs in this class 44 manufacturers

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Drugs in Cephalosporins - 1st Generation

Showing 64–70 of 70 drugs

CEPHALEXIN

BETA-LACTAMS · PHARYNGITIS DUE TO STREPTOCOCCUS PYOGENES ·+21
REMEDYREPACK, I

CEFADROXIL

BETA-LACTAMS · PHARYNGITIS DUE TO STREPTOCOCCUS PYOGENES ·+9
REMEDYREPACK, I

CEPHALEXIN

BETA-LACTAMS · PHARYNGITIS DUE TO STREPTOCOCCUS PYOGENES ·+21
AUROBINDO PHARM

CEPHALEXIN

BETA-LACTAMS · PHARYNGITIS DUE TO STREPTOCOCCUS PYOGENES ·+21
HAWAII REPACK,
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About Cephalosporins - 1st Generation.

First-generation cephalosporins are a therapeutic class of bactericidal beta-lactam antibiotics that include agents such as cefazolin, cephalexin, and cefadroxil.

They act by binding to penicillin-binding proteins, thereby disrupting bacterial cell wall synthesis and causing osmotic cell lysis.

These agents primarily target Gram-positive cocci—notably methicillin-susceptible *Staphylococcus aureus* and streptococcal species—along with select Gram-negative organisms like *Escherichia coli*, *Klebsiella pneumoniae*, and *Proteus mirabilis*.

Clinically, they are widely indicated for skin and soft tissue infections, uncomplicated urinary tract infections, bone infections, and perioperative surgical prophylaxis.