Complement Inhibitors

Complement inhibitors are a therapeutic drug class that selectively targets and modulates specific proteins or enzymatic pathways within the complement cascade of the innate immune system By blocking critical complement components—such as C1s, C3, C5, Factor B, Factor D, or related receptors—these agents prevent unregulated complement activation, thereby reducing downstream inflammation, opsonization, and membrane-attack-complex-mediated cell lysis They are primarily utilized in treating rare he...

Complement inhibitors are a therapeutic drug class that selectively targets and modulates specific proteins or enzymatic pathways within the complement cascade of the innate immune system By blocking critical complement components—such as C1s, C3, C5, Factor B, Factor D, or related receptors—these agents prevent unregulated complement activation, thereby reducing downstream inflammation, opsonization, and membrane-attack-complex-mediated cell lysis

They are primarily utilized in treating rare hematologic, renal, ophthalmologic, and autoimmune disorders driven by complement dysregulation, including paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis, and geographic atrophy

Due to their immunosuppressive mechanism, therapy often requires vigilant risk management for infections caused by encapsulated bacteria

Due to their immunosuppressive mechanism, therapy often requires vigilant risk management for infections caused by encapsulated bacteria